Results 231 to 240 of about 64,148 (296)

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

Determinants of old age disability in Botswana: an empirical investigation using generalized linear models. [PDF]

BMC Geriatr
Monamo TT, Keetile M, Letamo G.
europepmc   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Neuron synchronization analyzed through spatial-temporal attention. [PDF]

Front Comput Neurosci
Yang H, Kc P, Chen P, Lei H, Sponberg S, Tarokh V, Riffell JA.   +6 more
europepmc   +1 more source

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

Advanced Science, EarlyView.
Cyclic nucleotide‐gated (CNG) and hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels share substantial sequence and structural similarity but differ markedly in ion conductance and K+ selectivity. Microsecond‐scale atomistic MD simulations qualitatively reproduced the conductance differences observed in single‐channel recordings and ...
Haoran Liu, Klaus Benndorf, Yessenbek K. Aldakul, Han Sun   +3 more
wiley   +1 more source

Refinement of the novel tank diving test: toward standardized and robust analysis of anxiety-like behavior in zebrafish. [PDF]

Front Behav Neurosci
Shinkai T, Nakai M, Takeshita U, Morita K, Shimada Y.   +4 more
europepmc   +1 more source

Statistically principled feature selection for single cell transcriptomics. [PDF]

BMC Bioinformatics
Dollinger EP, Silkwood K, Atwood S, Nie Q, Lander AD.   +4 more
europepmc   +1 more source

Modeling the Dynamics of Electric Field-Assisted Local Functionalization in Two-Dimensional Materials. [PDF]

Materials (Basel)
Borrás F, Ramiro-Bargueño J, Casanova-Carvajal Ó, de Andrés A, Quesada SJ, Álvarez ÁL.   +5 more
europepmc   +1 more source

Fatal Dog Attacks in Italy (2009-2025): The Urgent Need for a National Risk Registry. [PDF]

Animals (Basel)
Iarussi F, Sessa F, Piccirillo S, Francaviglia M, Recchia A, Colella A, Bolcato M, Salerno M, Peli A, Pomara C.   +9 more
europepmc   +1 more source