Results 41 to 50 of about 93,578 (247)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On the issue of mistakes' diagnostics for recognizing and understanding compound words
Psichologija, 1977 Many unknown words in the text factor is one of the factors interfering with the synthetic comprehension of the text. When starting to prepare exercises that form the ability and skills to understand unknown words by reading a text, a pedagogical ...
A. Velička, J. Križinauskas
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Headedness and structure of Xitsonga compound words
LiteratorCompound words, formed by combining two or more morphemes, play a significant role in Xitsonga’s lexicon. This study employs a descriptive qualitative approach to examine how the head and modifier(s) interact to contribute to the overall structure and ...
Respect Mlambo +2 more
doaj +1 more source
COMPOUND WORDS THAT OCCUR DURING THE GLOBAL PANDEMIC COVID-19: A MORPHOSEMANTIC STUDY
English Review: Journal of English Education, 2020 This study aims to analyse and examine closely the category of compound words that occur during the global pandemic COVID-19 and their type of meaning. The method used in carrying out the study was a descriptive analysis method.
Ervina CM Simatupang, Ida Zuraida Supri
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
An Analysis of Persian Compound Nouns as Constructions [PDF]
Iranian Journal of Applied Language Studies, 2017 In Construction Morphology (CM), a compound is treated as a construction at the word level with a systematic correlation between its form and meaning, in the sense that any change in the form is accompanied by a change in the meaning.
Faezeh Arkan, Ali Safari
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