Results 111 to 120 of about 3,864,570 (332)

Investigation of a Compound Helicopter Flying the Depart and Abort Mission Task Element [PDF]

open access: yes, 2017
The next generation of rotorcraft will have to satisfy the appropriate handling qualities requirements before entering service. Many of these vehicles will operate at significantly greater speeds than the conventional helicopter and will therefore have
Anderson, Dave   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

An Overview of Proprietary Vehicles/Bases for Topical Compounding Medicines and Cosmetics

open access: yesCosmetics
Compounding is currently an integral part of pharmacy practice, and it is essential to the provision of healthcare. Compounding is an important therapeutic option in all areas of medicine, with relevance to dermatological treatments.
Ana Torres   +2 more
doaj   +1 more source

The Term Structure of Interest Rates [PDF]

open access: yes
This paper consolidates and interprets the literature on the term structure, as it stands today. Definitions of rates of return, forward rates and holding returns for all time intervals are treated here in a uniform manner and their interrelations, exact
J. Huston McCulloch, Robert J. Shiller
core  

EXTEMPORANEOUS COMPOUNDING PRACTICE BY PHARMACISTS: A SYSTEMATIC REVIEW

open access: yes, 2017
Objective: To identify the frequency and scope of extemporaneous compounding practice reported in community and hospital pharmacies. Method s : A systematic literature review was undertaken to identify the prevalence of extemporaneous compounding ...
S. Kristina   +3 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Forming new words: compounding in children with developmental language disorders

open access: yesFrontiers in Language Sciences
Compounding is a common word-formation strategy in Germanic languages such as English and German. This study focuses on German compounding, which is highly productive and frequently used to create new words.
Lisa Giesselbach, Anna-Lena Scherger
doaj   +1 more source

A Deeper Look at Hyperbolic Discounting [PDF]

open access: yes
We conduct an experiment to investigate the degree to which deviations from exponential discounting can be accounted for by the hypothesis of hyperbolic discounting. Subjects are asked to choose between an earlier or later payoff in a series of 40 choice
Sheth, Arnav, Sopher, Barry
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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