Results 161 to 170 of about 955,174 (332)

MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells [PDF]

Mitchell P. McInerney, Wael Awad, Michael N. T. Souter, Youngcheol Kang, Carl J. H. Wang, Kean Chan Yew Poa, Mohamed R. Abdelaal, Ngoc H. Le, Chloe M. Shepherd, Conor McNeice, Lucy J. Meehan, Adam G. Nelson, Jeremy M. Raynes, Jeffrey Y. W. Mak, James McCluskey, Zhenjun Chen, Ching‐Seng Ang, David P. Fairlie, Jérôme Le Nours, Patricia T. Illing, Jamie Rossjohn, Anthony W. Purcell   +21 more
openalex   +1 more source

Effect of Herbal Feed Additives on Goat Milk Volatile Flavor Compounds [PDF]

, 2023
J. Wójtowski, Małgorzata Majcher, R. Danków, J. Pikul, Przemysław Ł. Mikołajczak, Marta Molińska-Glura, Joanna Foksowicz‐Flaczyk, Agnieszka Gryszczyńska, Zdzisław Łowicki, Karolina Zajączek, Grażyna Czyżak‐Runowska, Maria Markiewicz‐Kęszycka, Daniel Stanisławski   +12 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Extemporaneous Formulations for Pediatric Patients: Global Necessities, Challenges and Opportunities. [PDF]

Pharmaceutics
Pai VB, Nahata MC.
europepmc   +1 more source

GC-MS Analysis of Compounds Extracted from Buds of Populus balsamifera and Populus nigra [PDF]

, 2003
Valery A. Isidorov, Vera T. Vinogorova
openalex   +1 more source

Phenolic and terpene compounds from Plectranthus amboinicus (Lour.) Spreng. Act as promising hepatic anticancer agents screened through in silico and in vitro approaches

, 2022
M Sindhu, Mani Poonkothai, Thirumalaisamy Rathinavel   +2 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Adverse drug events from paediatric use of extemporaneously compounded medicines in community pharmacy settings: a scoping review. [PDF]

BMJ Paediatr Open
Li J, Buckley NA, Lee J, Cairns R.
europepmc   +1 more source