Results 141 to 150 of about 871,936 (333)
Commentaire - Améliorer notre compréhension de l’épidémie de surdoses liées aux opioïdes de médicaments et de drogues illicites contaminées au Canada [PDF]
, 2018 Robert Strang
openalex +1 more source
Compréhension des perturbations accidentelles du mouvement dans l’activité dans une perspective de prévention [PDF]
, 2022 Sylvie Leclercq, Alain Garrigou
openalex +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
La fluidité : un moyen pour évaluer la compréhension de l’écrit
Langues & CulturesIl nous a été donné de constater que des élèves de 4ème année moyen rencontraient des difficultés à accéder au sens des textes alors que les directives officielles affirmaient qu’ils étaient en mesure de comprendre tous les types d’écrits.
Imane MISSOUM BENZIANE +1 more
doaj
The economics and business models of prescription in the Internet [PDF]
L'économie de l'Internet a contribué à une ouverture du jeu concurrentiel en dissociant les fonctions physique et informationnelle des activités de distribution.
Pierre-Jean Benghozi, Thomas Paris
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
La compréhension des phrases simples comportant des marqueurs de relations spatiales.
, 1978 International audienceBoth the use of three modes of interpretation (pragmatic, semantic and syntactic) and the incidence of this use on the understanding of six spatial location marks are investigated in children 2,8 to 4,7 years of age.
Vion, Monique
core +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source