Results 51 to 60 of about 719,561 (338)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
A Comprehensive Approach to Preceptor Development [PDF]
American Journal of Pharmaceutical Education, 2012 To assess the impact of a comprehensive preceptor development program.A comprehensive preceptor development program was designed that included live and recorded online programming, a preceptor manual, a preceptor newsletter, live events (local and regional), and one-on-one practice site visits.Over 5,000 evaluations (1,900 pre-implementation and 3,160 ...
Susan S. Vos, CoraLynn B. Trewet
openaire +3 more sources
Understanding object-oriented source code from the behavioural perspective [PDF]
, 2005 Comprehension is a key activity that underpins a variety of software maintenance and engineering tasks. The task of understanding object-oriented systems is hampered by the fact that the code segments that are related to a user-level function tend to be ...
Roper, M., Walkinshaw, N., Wood, M.
core +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
C4ISR: A Comprehensive Approach [PDF]
Information & Security: An International Journal, 2011 In this keynote speech the NC3A General Manager identifies several key lessons from current operations and ways of developing capabilities, including the lack of agility, coherence and upfront interoperability. In dealing with current operational and capability development challenges, NATO and the member nations need to identify overlaps and ...
openaire +2 more sources
Learning Language from a Large (Unannotated) Corpus [PDF]
, 2014 A novel approach to the fully automated, unsupervised extraction of dependency grammars and associated syntax-to-semantic-relationship mappings from large text corpora is described.
Goertzel, Ben, Vepstas, Linas
core
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
Embodied language understanding requires an enactivist paradigm of cognition
Frontiers in Psychology, 2010 Two recurrent concerns in discussions on an embodied view of cognition are the ‘necessity question’ (i.e. is activation in modality-specific brain areas necessary for language comprehension?) and the ‘simulation constraint’ (i.e.
Michiel eVan Elk +3 more
doaj +1 more source
Intelligent Biofeedback Augmented Content Comprehension (TellBack)
IEEE Access, 2021 Assessing comprehension difficulties requires the ability to assess cognitive load. Changes in cognitive load induced by comprehension difficulties could be detected with an adequate time resolution using different biofeedback measures (e.g., changes in ...
Haytham Hijazi +5 more
doaj +1 more source