Results 111 to 120 of about 8,657,385 (309)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Report of the IEA Workshop on Evaluating the Quality of Science, Rome, 10-11 December 2015

, 2020
IEA organized a 1.5 day (10-11 December 2015) internal workshop to discuss approaches and experiences in assessing science quality, primarily through evaluations in the CGIAR.
CGIAR Independent Evaluation Arrangement
core  

Construction of a Machine Learning-Based Risk Prediction Model for Drug-Induced Acute Kidney Injury in Elderly Patients

International Journal of Nephrology and Renovascular Disease
Xiayan Xu,1,* Haoting Huang,2,* Yan Xu,3 Ying Liu,3 Jiamei Yi,1 Qingrong Zou,1 Jianru Wu,2 Xiaoyu Liu21Department of Pharmacy, Shenzhen Luohu People’s Hospital (The Third Affiliated Hospital of Shenzhen University), Shenzhen, Guangdong ...
Xu X, Huang H, Xu Y, Liu Y, Yi J, Zou Q, Wu J, Liu X   +7 more
doaj  

A Systematic Review of Green Port Evaluation: Methods, Subjects, and Indicators

Journal of Marine Science and Engineering
In the context of global carbon neutrality goals and the transition to clean energy, ports have become a focal point due to their significant energy consumption and pollution emissions. This heightened attention has promoted research on green ports, with
Huaping Fei, Hongda Shi, Xinying Pan
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Evaluation of Scaling Efforts in CGIAR: Technical Note

CGIAR has maintained a long-standing commitment to scaling the public benefits of its innovations and has recently reinforced this priority. This renewed emphasis has generated an increasing need for the systematic evaluation of scaling efforts.
CGIAR Independent Advisory and Evaluation Service
core  

Assessment of Soil Comprehensive Nutrients Status in Irrigation District of Yellow River Based on GIS

Shuitu baochi yanjiu, 2010
The precision agriculture is the development direction of the future agriculture and investigating the soil properties and the spatial variability of the productivity is the basic research content of the precision agriculture.In this paper,soil fertility
XIAO Lian-gang, ZHANG Jian-ming
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source