Results 211 to 220 of about 137,196 (298)

Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Clinical outcome assessments (COAs) are essential for evaluating symptom severity, treatment response, and disease progression in Parkinson's disease (PD). As clinical knowledge evolves, it is necessary to revisit the recommendation status on the COAs to ensure their continued relevance and validity. Objectives To provide an updated
Evita Papathoma, Panagiota Tsitsi, Nirosen Vijiaratnam, Camila Aquino, Stephen R. Duma, Norbert Kovacs, Kigocha Lameck Okeng'o, Aparna Wagle Shukla, Roongroj Bhidayasiri, Tiago A. Mestre, Alvaro Sanchez Ferro, Alberto J. Espay, Michelle H.S. Tosin, Matej Skorvanek, Ioanna Markaki   +14 more
wiley   +1 more source

Comprehensive geriatric assessment (CGA) scale does not effectively identify elderly AML patients suitable for intensive induction chemotherapy - a multicenter study from Polish Adult Leukemia Group. [PDF]

Ann Hematol
Budziszewska BK, Łomiak M, Barankiewicz J, Patkowska E, Helbig G, Bołkun Ł, Irga-Staniukiewicz A, Kiżewska A, Piekarska A, Koclęga A, Pluta A, Kuydowicz M, Kościołek-Zgódka S, Cichocka E, Malenda A, Wójcik K, Gromek T, Małecki P, Grosicki S, Giebel S, Wierzbowska A, Lech-Marańda E.   +21 more
europepmc   +1 more source

Clinical and Imaging Characteristics of Parkinson's Disease with Negative Alpha‐Synuclein Seed Amplification Assay

Movement Disorders, EarlyView.
Abstract Background The cerebrospinal fluid alpha‐synuclein seed amplification assay (CSFasynSAA) detects alpha‐synuclein aggregation in over 90% of individuals with sporadic PD (sPD). However, the clinical characteristics of sPD with negative CSFasynSAA remain undefined.
Sarah M. Brooker, Jacopo Pasquini, Seung Ho Choi, David‐Erick Lafontant, Seyed‐Mohammad Fereshtehnejad, Yashar Zeighami, Piergiorgio Grillo, Giulietta M. Riboldi, Houman Azizi, Roqaie Moqadam, Un Jung Kang, Kelly N.H. Nudelman, Andrew Siderowf, Caroline M. Tanner, Thomas F. Tropea, Tatiana Foroud, Lana M. Chahine, Brit Mollenhauer, Kalpana M. Merchant, Douglas Galasko, Christopher S. Coffey, Roseanne D. Dobkin, Ethan G. Brown, Roy N. Alcalay, Daniel Weintraub, Kenneth Marek, Tanya Simuni, Paulina Gonzalez‐Latapi, Nicola Pavese, Kathleen L. Poston, the Parkinson's Progression Markers Initiative   +30 more
wiley   +1 more source

Temporal Dynamics of Parkinson's Disease Tremor: Clinical and Neuroimaging Insights

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder clinically defined by three cardinal motor symptoms: bradykinesia, rigidity, and tremor. Although the natural history of bradykinesia and rigidity is well described, the evolution of tremor as the disease progresses remains controversial. Objectives The goal was to
Melanie Suette, Robert Matic, Marisa Koini, Lukas Gattermeyer‐Kell, Daniela Kern, Petra Katschnig‐Winter, Mariella Koegl, Maximilian Sackl, Christian Tinauer, Birgit Helmlinger, Manuel Leitner, Stefan Ropele, Daniela Pinter, Christian Enzinger, Stephan Seiler, Petra Schwingenschuh   +15 more
wiley   +1 more source

Implementing comprehensive geriatric assessment in an academic hematologic outpatient setting: experiences from medical doctors and patients. [PDF]

Front Oncol
Hiltgen SP, Bischoff-Ferrari HA, Gagesch M, Kaltenborn A, Manz MG, Rieger MJ, Schwotzer R, Stolz SM, Zenz T, Rösler W.   +9 more
europepmc   +1 more source

Temporal Interference Stimulation Modulates Resting State Functional Connectivity of Motor Circuit in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Transcranial temporal interference stimulation (TIs) targeting the subthalamic nucleus (STN) is a novel noninvasive neuromodulation approach with potential to improve motor symptoms in Parkinson's disease (PD). However, its underlying neuroimaging mechanisms remain unclear.
Yongxin Xu, Chenhao Yang, Yichao Du, Xiaonan Shen, Tingting Li, Yufeng Zhang, Zijun Lu, Jie Zhuang, Nan Chen, Yulian Zhu, Chencheng Zhang, Jiaojiao Lü, Lingyan Huang, Lu Li, Jianqiang Lü, Zhenyu Qian, Zhen Wang, Jian Zhang, Junhong Zhou, Yu Liu   +19 more
wiley   +1 more source

Identifying Risk Factors for Delirium Through Comprehensive Geriatric Assessment in Older Adults Receiving Palliative Cancer Care. [PDF]

Nurs Rep
Llisterri-Sánchez P, Martínez-Arnau FM, Pérez-Ros P.   +2 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Comprehensive geriatric assessment in nonhospitalized settings: An overview of systematic reviews. [PDF]

Geriatr Gerontol Int
Kshatri JS, Janssen DJA, Shenkin SD, Mansingh A, Pati S, Palo SK, Pati S.   +6 more
europepmc   +1 more source

Mental Health and Corresponding Interventions for Persons With Physical Disabilities: A Scoping Review

Medicine Advances, EarlyView.
This scoping review of 33 studies maps the landscape of mental health in persons with physical disabilities. It finds a high prevalence of depression, anxiety, posttraumatic stress disorder, and other psychological problems, but highlights significant heterogeneity across studies in sample size, measurement, and representativeness.
Hui Li, Mengqian Li, Hongguang Chen, Xueting Bai, Qi Qiu, Nanqi Fan, Xin Wu, Xing Wang   +7 more
wiley   +1 more source