Results 81 to 90 of about 509,724 (273)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Older people and medication taking behaviour: A review of the literature [PDF]

, 2008
Background: Older people represent a sizeable population of the UK. Many older people receive drug treatment for long term conditions. Adherence with medication is therefore an important clinical, financial and resource intensive concern.
Barber, Belcher, Benson, Benson, Blaxter, Bonner, Butler, Campbell, Carr, Chen, Chin, Cline, Cohen, Conrad, Corlett, De Geest, Dowell, Dunbar-Jacob, Ekman, Griffiths, Harrison, Hughes, Johnson, Kippen, Kjellgren, Kjellgren, Kripalani, Lee, Leventhal, Levy, Lumme-Sandt, Maggi Banning, Maidment, Mallion, Mancia, Mays, McElnay, Phatak, Pound, Pound, Roth, Sackett, Salas, Sale, Scotto, Senior, Struthers, Svensson, Unson, Van der Wal, Veehof, Vermiere, Watson, Zafran   +53 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Value Driven Pharmacist: Basics of Access, Cost, and Quality 2nd Edition [PDF]

, 2020
https://digitalcommons.butler.edu/butlerbooks/1017/thumbnail ...
Devine, Trish, Jordan, Joseph, Knoderer, Chad, McFarland, Annette, Smith, Carriann, Wilhoite, Jessica   +5 more
core   +1 more source

Measuring the burden of treatment for chronic disease: implications of a scoping review of the literature [PDF]

, 2017
Background: Although there has been growing research on the burden of treatment, the current state of evidence on measuring this concept is unknown.
Mair, Frances S., McMillan, Sara S., Salehi, Asiyeh, Sav, Adem   +3 more
core   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Where are the Ambulatory Care Pediatric Pharmacists?

Children, 2019
This editorial describes the purposes and content of the Special Issue for the development of a national pediatric pharmacotherapy collaborative practice network.
Richard H. Parrish, Johannes van den Anker, Sandra Benavides   +2 more
doaj   +1 more source

Hospice Palliative Home Care in Canada: A Progress Report [PDF]

, 2008
This report is a snapshot of hospice palliative home care services available to Canadians in 2008. The information refers only to hospice palliative care services provided in the home.
Jean Bacon
core  

Four patients with a history of acute exacerbations of COPD: implementing the CHEST/Canadian Thoracic Society guidelines for preventing exacerbations [PDF]

, 2015
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
A Singanayagam, AJ Crockett, AL Ries, AM Yohannes, C Fletcher, CE Bucknall, CM Fletcher, CP Hersh, D Brooks, DD Marciniuk, F Maltais, FA Cleutjens, G Guyatt, GJ Criner, J Chong, J Pynoos, J Strijbos, JJ Soler-Cataluna, JW Dodd, K Gruffydd-Jones, K Rockwood, K Rockwood, KH Groenewegen, L Cheyne, L Lahousse, L Puente-Maestu, LP Fried, LS Bickford, M Guell, M Stickland, M Zwerink, MM Ball, P Almagro, PG Gibson, PW Jones, S Hull, SK Park, SP Newman, T Bodenheimer, T Lee, TM Wilkinson, VS Fan, World Health Organization, Y Lacasse   +43 more
core   +1 more source