Results 291 to 300 of about 196,114 (350)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

A Chemical Bonding Interpretation of Unusual Compressibility Trends in Hydrated Magnesium Sulfates. [PDF]

Inorg Chem
Kebede GG, Franco R, Izquierdo-Ruiz F, Lobato A, Recio JM.   +4 more
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Highly Elastic and Conductive Lamellar Wood Sponge via Cell Wall Reconfiguration Toward Smart Multifunctional Applications. [PDF]

Nanomicro Lett
Dai XJ, Wang X, Hu JH, Jiang P, Wang XQ.
europepmc   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Comparative High-Pressure Study on Rare-Earth Entropy Fluorite-Type Oxides. [PDF]

Cryst Growth Des
Botella P, Vie D, Kolarek L, Bura N, Zhang P, Herlihy A, Daisenberger D, Popescu C, Errandonea D.   +8 more
europepmc   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Effect of Waste Tire Particle Content on the Compressive Behavior and Pore Structure of Loess Subgrade Materials. [PDF]

Materials (Basel)
Cao X, Liu Y, Wu X, Han M, Liu X.
europepmc   +1 more source

Two-dimensional steady nonviscous and viscous compressible flow through a system of equidistant blades

, 1952
Hans Reissner, L Meyerhoff, Martin H. Bloom   +2 more
openalex   +1 more source

Compressibility and Rheology of Clay Tailings: Effects of Sodium Polyacrylate in Presence of Divalent Cations. [PDF]

Polymers (Basel)
Nieto S, Piceros E, Castañeda Y, Robles P, Leiva W, Quezada GR, Jeldres RI.   +6 more
europepmc   +1 more source