Results 91 to 100 of about 1,021,265 (299)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Compression-Driven Test Access Mechanism Design Approach

, 2004
Driven by the industrial need for low-cost test methodologies, the academic community and the industry alike have put forth a number of efficient test data compression (TDC) methods. In addition, the need for core-based System-on-a-Chip (SoC) test led to
Gonciari, Paul Theo, Al-Hashimi, Bashir
core   +1 more source

Effect of upper lip compression on pain reduction during local anesthesia. A split-mouth randomized clinical trial

International Journal of Interdisciplinary Dentistry, 2023
Objectives: To evaluate the effect of pressure on the skin of upper lip in decreasing pain perception during a local maxillary anesthetic injection. Material and Methods: A split-mouth crossover randomized clinical trial was designed.
Pedro Christian Aravena, Sergio Lagos-Mediavilla, Javier Loaysa-Tobar, César Coronado-Gallardo, Mario Felipe Gutiérrez, Rodolfo Miralles   +5 more
doaj   +1 more source

Compressed Counting Meets Compressed Sensing

CoRR, 2013
Compressed sensing (sparse signal recovery) has been a popular and important research topic in recent years. By observing that natural signals are often nonnegative, we propose a new framework for nonnegative signal recovery using Compressed Counting (CC).
Ping Li 0001, Cun-Hui Zhang, Tong Zhang 0001   +2 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Prehospital randomised assessment of a mechanical compression device in cardiac arrest (PaRAMeDIC) trial protocol [PDF]

, 2010
Background Survival after out-of-hospital cardiac arrest is closely linked to the quality of CPR, but in real life, resuscitation during pre-hospital care and ambulance transport is often suboptimal.
Matthew W Cooke, Cooke, MW, Slowther, A, Quinn, Tom, Deakin, Charles D., Lamb, Sarah E, Jessica Horton, Woollard, M, Lall, Ranjit, McCabe, Chris, Deakin, C, Perkins, Gavin D., Gates, S, Tom Quinn, Lamb, S. E., Chris McCabe, Slowther, Anne, McCabe, Christopher, Perkins, GD, Horton, J, Perkins, Gavin, Lall, R, Malcolm Woollard, Cooke, Matthew W, Anne Slowther, Woollard, Malcolm, Cooke, Matthew, Gates, Simon, Lamb, Sarah, Charles Deakin, Sarah E Lamb, Gavin D Perkins, Perkins, Gavin D, Simon Gates, Deakin, Charles, Horton, Jessica, McCabe, C, Quinn, T, Ranjit Lall, Lamb, SE   +39 more
core   +2 more sources

Test data compression: The system integrator’s perspective

, 2003
Test data compression (TDC) is a promising low-cost methodology for System-on-a-Chip (SOC) test. This is due to the fact that it can reduce not only the volume of test data but also the bandwidth requirements.
Gonciari, Paul Theo, Al-Hashimi, Bashir, Nicolici, Nicola   +2 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Effects of different pressure midfoot wraps on balance and proprioception in amateur basketball athletes

Frontiers in Bioengineering and Biotechnology
IntroductionAnkle sprains are prevalent in basketball. This study sought to determine how midfoot wraps affect postural stability and ankle proprioception.MethodsTwenty-two amateur basketball athletes performed three single-leg balance tests (static ...
Chengliang Wu, Shuai Zhang, Tao Wu, Sheng-Wei Jia, Zhaowei Chu, Fan Yang   +5 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source