Results 161 to 170 of about 9,056 (295)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

A cross-sectional study of the use of graduated compression stockings at two top end hospitals in Darwin, Australia. [PDF]

J Vasc Surg Venous Lymphat Disord
Byrnes JM, Commons RJ, Hamilton MJ, Bowden J, Ton T, Tole DT, Quader S, Wang Y, Vincent S, Jenkins L, Lu M, Wong J, Yun R, Sun J, Gordon A, McCallum GB.   +15 more
europepmc   +1 more source

Positive perception and efficacy of compression stockings for prevention of lower limb edema in pregnant women. [PDF]

J Vasc Bras, 2022
Saliba-Júnior OA, Rollo HA, Saliba O, Sobreira ML.   +3 more
europepmc   +1 more source

High Free‐Volume Imidazole‐Based Ionomers for High‐Temperature Proton Exchange Membrane Fuel Cells

Advanced Science, EarlyView.
High free‐volume imidazole‐based ionomers (PF4IM‐72) enable enhanced phosphoric acid uptake and efficient proton transport, delivering peak power densities of 0.645 W cm−2 at 160 °C and 0.838 W cm−2 at 200 °C in HT‐PEMFCs. This work highlights a promising platform for next‐generation ionomers with improved high‐temperature performance and stability ...
Ge Chao, Hyeon Keun Cho, Chang Yeon Hyun, Shirong Li, Jong Geun Seong, So Young Lee, Nanwen Li, Young Moo Lee   +7 more
wiley   +1 more source

Graded Compression Stockings Prevent Post-spaceflight Orthostatic Hypotension

, 2009
Post-spaceflight orthostatic intolerance is characterized by hypotension and presyncope in 20-30% of returning astronauts. Previous data from our laboratory suggests that this is largely a result of decreased venous return.
Locke, J., Stenger, M. B., Platts, S. H., Brown, A. K.   +3 more
core  

Hybrid Finite Element Model for Predicting the Interface Pressure of Medical Compression Stockings. [PDF]

Int J Numer Method Biomed Eng
Pita Miguélez I, Labanieh AR, Soulat D.
europepmc   +1 more source

Graduated compression stockings for the initial treatment of varicose veins in people without venous ulceration. [PDF]

Cochrane Database Syst Rev, 2021
Knight Nee Shingler SL, Robertson L, Stewart M.   +2 more
europepmc   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Effectiveness of long-term graduated compression stockings after deep vein thrombosis: a GRADE-based meta-analysis of randomized controlled trials. [PDF]

Front Med (Lausanne)
Duan Y, Liu J, Lin S, Li X, Luo D, Zhu L.   +5 more
europepmc   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source