Results 241 to 250 of about 9,056 (295)

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source

Medical elastic compression stockings

, 2009
openaire   +1 more source

Quantifying the Degree Graduated Elastic Compression Stockings Enhance Venous Emptying

European Journal of Vascular and Endovascular Surgery, 2014
ObjectivesGraduated elastic compression (GEC) stockings reduce reflux and venous volume but their performance on augmenting venous return is unproven. The aim of this study was to quantify the ability of stockings to increase venous outflow from the leg ...
Christopher R Lattimer, G Geroulakos
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Graded Compression Stockings

Archives of Surgery, 1982
Graded compression stockings of the leg (high pressure at the ankle and low pressure at the thigh) seem to help the return of venous blood to the heart and reduce the incidence deep-vein thrombosis and pulmonary emboli in supine patients. Recent advances allow noncustom stockings to be chosen for mesomorphic patients by leg length and calf ...
G, Johnson, C, Kupper, D J, Farrar, R T, Swallow   +3 more
openaire   +2 more sources

Challenging the evidence for graduated compression stockings

BMJ, 2013
Welfare highlights important points surrounding the recommended use of anticoagulants to prevent venous thromboembolism (VTE).1 We highlight problems surrounding National Institute for Health and Care Excellence (NICE) recommendations that all hospital inpatients, excluding those with stroke, are considered for mechanical prophylaxis.
Laurence, Whittaker, Trevor, Baglin, Alain, Vuylsteke   +2 more
openaire   +2 more sources

Efficacy of compression stockings in preventing post-thrombotic syndrome in patients with deep venous thrombosis: a systematic review and metaanalysis

Vasa - European Journal of Vascular Medicine, 2016
Background: Here, we update an earlier systematic review on the preventive efficacy of active compression stockings in patients with diagnosed proximal deep venous thrombosis (DVT) by including the results of recently published trials.
Jakob M Burgstaller, Johann Steurer, Ulrike Held   +2 more
exaly   +2 more sources

Graduated Compression Stockings

Clinical Orthopaedics and Related Research, 2001
The mechanisms by which graduated compression stockings prevent deep venous thrombosis are not completely understood. In the current study the physiologic effect of low-pressure graduated compression stockings on the venous blood flow in the lower limb and the practical aspects of their use were assessed. Patients having elective orthopaedic surgery at
T, Benkö, E A, Cooke, M A, McNally, R A, Mollan   +3 more
openaire   +2 more sources

Pressure profiles of sport compression stockings

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2016
SummaryBackgroundWhile sport compression stockings (SCS) have become increasingly popular, there is no regulatory norm as exists for medical compression stockings (MCS). The objective of this pilot study was to compare five SCS with respect to their pressure profiles ex vivo and in vivo, and in relation to German standards for MCS (RAL norm).Patients ...
Stefanie, Reich-Schupke, Stefan, Surhoff, Markus, Stücker   +2 more
openaire   +2 more sources

Venous haemodynamics and the effects of compression stockings

British Journal of Community Nursing, 2001
Over the years, graduated compression stockings exerting varying ankle pressures have been used with differing degrees of effectiveness in the prevention of deep venous thrombosis and ulcer recurrence, and the treatment of venous ulceration (Stemmer et al, 1980; Partsch and Horakova, 1994; Veraart et al, 1997).
openaire   +2 more sources