Results 41 to 50 of about 3,016,463 (292)

Supervised exercise training as an adjunctive therapy for venous leg ulcers: study protocol for a randomised controlled feasibility trial [PDF]

open access: yes, 2015
Background Venous leg ulcers are common, chronic wounds that are painful and reduce quality of life. Compression therapy is known to assist in the healing of venous leg ulceration.
Gumber, Anil   +18 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

On the performance of markup language compression [PDF]

open access: yes
Data compression is used in our everyday life to improve computer interaction or simply for storage purposes. Lossless data compression refers to those techniques that are able to compress a file in such ways that the decompressed format is the replica ...
Kheirkhahzadeh, Antonio
core   +3 more sources

Silicone Elastomeric-Based Materials of Soft Pneumatic Actuator for Lower-Limb Rehabilitation: Finite Element Modelling and Prototype Experimental Validation

open access: yesApplied Sciences, 2023
This study describes the basic design, material selection, fabrication, and evaluation of soft pneumatic actuators (SPA) for lower-limb rehabilitation compression therapy.
Hanisah Bakeri   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Validation of a test setup for measuring compression load under elements of multilayer bandages: an in vitro study

open access: yesСеченовский вестник
Aim. To develop and validate a test setup for measuring the load under compression elements (CE) of multilayer bandages composed of materials with different stiffness.Materials and methods.
S. K. Zazulin   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Image compression with anisotropic diffusion [PDF]

open access: yes, 2008
Compression is an important field of digital image processing where well-engineered methods with high performance exist. Partial differential equations (PDEs), however, have not much been explored in this context so far. In our paper we introduce a novel
Welk, Martin   +19 more
core   +1 more source

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