Results 51 to 60 of about 27,372 (299)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Lazos compulsivos de la violencia y ecos sadianos
Desde el Jardín de Freud, 2015 El trabajo expone los lazos que instaura la violencia en la reproducción de las intransigencias superyoicas. Advierte sobre las consecuencias de una compulsión a la violencia, que encuentra en la guerra su razón suprema.
Mario Orozco Guzmán
doaj +3 more sources
, 1999 Catalogue for an exhibition by ten artists working with the theme of “compulsion.” Massier proposes that the works reflect the personal and mutable nature of the creative impulse. He comments on each work, examining how compulsion acts as a poetic device,
Liss, David, Massier, John
core +1 more source
Frontiers in Pharmacology, 2013 A large subgroup of around 25% of schizophrenia patients suffers from obsessive-compulsive symptoms (OCS) and about 12% fulfil the diagnostic criteria of obsessive-compulsive disorder (OCD).
Frederike eSchirmbeck, Mathias eZink
doaj +1 more source
, 2017 Outreach is particularly needed for patients with limited insight into their need for treatment. This chapter examines the concept of insight and the practices used to support it and to ensure treatment despite its limitations.
Mike Firn, Tom Burns
core +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
A Psychophysical Window onto the Subjective Experience of Compulsion
, 2021 In this perspective, we follow the idea that an integration of cognitive models with sensorimotor theories of compulsion is required to understand the subjective experience of compulsive action.
Wagner, Gerd +7 more
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Mystical analasis on Detachment of obligation's and secondary prayers's affects in nearness to God [PDF]
Pizhūhish/hā-yi Falsafī- Kalāmī, 2018 The Muslim mystics have various conducts based on diversities of states such as "qorbe farzi" and "qorbe nafli". Some of them are nafli and the others are farzi and the others are inclusive of the both, and finally, some of the mystics have the situation
سید احمد غفاری قره باغ
doaj +1 more source
The transition to compulsion in addiction
, 2020 Compulsion is a cardinal symptom of drug addiction (severe substance use disorder). However, compulsion is observed in only a small proportion of individuals who repeatedly seek and use addictive substances.
Luescher, Christian +8 more
core +1 more source