Results 41 to 50 of about 71,142 (262)

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source

Improving obsessive-compulsive buying through brand attachment and hedonic value: customer-based brand value

Business: Theory and Practice
This study aims to explore how hedonic value influences obsessive-compulsive buying behavior by examining the mediating roles of brand attachment and customer-based brand value. The research addresses inconsistencies in previous studies on the influence
Roymon Panjaitan, Irawan Yuswono, Arif Afendi, Elia Ardyan   +3 more
doaj   +1 more source

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source

When helping hurts: validating a measure of compulsive helping and exploring potential correlates

Frontiers in Psychology
IntroductionThis cross-sectional study proposes and validates a new measure of compulsive helping: helping which harms the helper.MethodsEmerging Adults (N = 438; Mage = 20.29, SD = 1.04, 51.71% Female) reported on compulsive helping. Confirmatory factor
Katey Workman, Laura M. Padilla-Walker, Peter J. Reschke, Adam A. Rogers   +3 more
doaj   +1 more source

Mental Health Stigma in Psychiatric Genetics: Insights and Recommendations From the ISPG Member Survey on Stigma

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Little is known about how stigma is perceived within psychiatric genetics, a field increasingly central to public discussions about heredity, neurodiversity, and psychiatric risk. Understanding how stigma is perceived and experienced by psychiatric geneticists is important for guiding responsible communication and future stigma‐reduction ...
Anaïs B. Thijssen, Elleke Tissink, Reeteka Sud, Mandy Johnstone, Richard Josiassen, Andrea Lahti, Laura Huckins, Ariana Page, Stigma Reduction Interest Group of the ISPG, Jordan W. Smoller, Jehannine Austin, Janneke Zinkstok, Sarah E. Medland, Rada Veeneman, Anna R. Docherty   +14 more
wiley   +1 more source

Influence of Molecular Genetic Classes on Behavior in Prader‐Willi Syndrome

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A wide range of behavioral phenotypes has been described in PWS patients including autism spectrum disorder (ASD). The prevalence of behavioral disorders was studied in 292 participants over 3 years with genetically confirmed PWS (N = 164 females and N = 128 males) with deletion (N = 182) and mUPD (maternal uniparental disomy) (N = 99).
Ranim Mahmoud, Merlin G. Butler, Wai Park, Jennifer L. Miller, Daniel J. Driscoll, June‐Anne Gold, Virginia Kimonis   +6 more
wiley   +1 more source

Pain and Problem Behavior in Cats and Dogs

Animals, 2020
We argue that there is currently an under-reporting of the ways in which pain can be associated with problem behavior, which is seriously limiting the recognition of this welfare problem.
Daniel S. Mills, Isabelle Demontigny-Bédard, Margaret Gruen, Mary P. Klinck, Kevin J. McPeake, Ana Maria Barcelos, Lynn Hewison, Himara Van Haevermaet, Sagi Denenberg, Hagar Hauser, Colleen Koch, Kelly Ballantyne, Colleen Wilson, Chirantana V Mathkari, Julia Pounder, Elena Garcia, Patrícia Darder, Jaume Fatjó, Emily Levine   +18 more
doaj   +1 more source

Social Determinants of Health and Health‐Related Quality of Life: The Potential Mediating Role of Social Activities, Access to Medical Services, and Access to Social Services

Australian Journal of Social Issues, EarlyView.
ABSTRACT This study explored the mediating influences of access to social activities, social services, and health and medical services on the relationship between social determinants of health and health‐related quality of life. A survey of 602 adults was conducted in a regional area of Australia.
Candice Oster, Ashleigh Powell, Claire Hutchinson, Richard Leibbrandt, Svetlana Bogomolova   +4 more
wiley   +1 more source

The relationship between compulsive shopping behavior, family functioning, and fashion orientation among female students: a descriptive cross-sectional correlational study

BMC Psychology
Background Compulsive shopping, a dysfunctional behavior with psychological, financial, and social consequences, is a growing concern, especially among students. Given the potential influence of family functioning and fashion orientation on this behavior,
Fatemehsadat Baniashraf, Maryam Madineshat, Erfan Ayubi, Efat Sadeghian, Mona Arji   +4 more
doaj   +1 more source

A Higher-Order Model of Flow and Impulsive–Compulsive Buying in Online Shopping: The Role of Hedonic and Utilitarian Browsing Motives [PDF]

Journal of Applied Structural Equation Modeling
The purpose of this study is to empirically investigate the impact of hedonic and utilitarian browsing orientations on flow experience and their relationship with impulsive and compulsive purchasing behavior in e-commerce settings.
Rullynta Siska Suryandari, Fahrais Zahrudy   +1 more
doaj   +1 more source