Results 61 to 70 of about 154,390 (283)

The Inadvisability of Nonuniformity in the Licensing of Cover Songs [PDF]

, 2016
In February 2015, the U.S. Copyright Office released a report entitled Copyright and the Music Marketplace, which summarizes its study of the music industry and recommends significant revisions to copyright law in response to the rapidly changing demands
King, Yolanda M.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Logic & Limits of the Exceptional Circumstances Test in Magill and IMS Health [PDF]

, 2004
In this Article, we show that, in contrast to the Commission\u27s balancing approach in Microsoft, the ECJ\u27s narrow construction of the obligation to license IP under Article 82 of the EC Treaty is based on sound economics and constitutes appropriate
Ahlborn, Christian, Evans, David S., Padilla, A. Jorge   +2 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Editorial

Condensed Matter Physics, 2020
Dear readers, We would like to thank you for being with us, both as readers and contributors to Condensed Matter Physics. Our special thanks are given to the referees for their time-consuming and noble efforts towards thorough reviewing the submitted ...
Editorial Board
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Zadania inwestycyjne jednostek samorządu terytorialnego województwa lubelskiego w zakresie ochrony zdrowia = Investment projects of local government units in the province of Lublin about health care

Journal of Education, Health and Sport, 2016
Warchoł Martyna, Furtak-Niczyporuk Marzena, Pachuta Małgorzata. Zadania inwestycyjne jednostek samorządu terytorialnego województwa lubelskiego w zakresie ochrony zdrowia = Investment projects of local government units in the province of Lublin about ...
Martyna Warchoł, Marzea Furtak-Niczyporuk, Małgorzata Pachuta   +2 more
doaj   +3 more sources

Student experiences and perceptions of compulsory research projects: a veterinary perspective [PDF]

, 2017
Background Although research underpins clinical work, many students training to be clinicians are not inherently interested in developing research skills.
Baxter Magolda, Braun, Bruner, Bruner, Bryman, Burgoyne, Cleland, Dale, Davis, Deci, Fraser, Funston, Garcia, Greenhalgh, Heath, Hunter, Husman, Ivankova, Krueger, Laidlaw, McManus, Miles, Murray, Park, Piaget, Rosol, Russell, Ryan, Sackett, Selbourne, Stubbs, Todd, Vygotsky, Weller, Wood, Wood   +35 more
core   +2 more sources