Results 101 to 110 of about 2,939,429 (324)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Cortical response states for enhanced sensory discrimination

eLife, 2017
Brain activity during wakefulness is characterized by rapid fluctuations in neuronal responses. Whether these fluctuations play any role in modulating the accuracy of behavioral responses is poorly understood.
Diego A Gutnisky, Charles Beaman, Sergio E Lew, Valentin Dragoi   +3 more
doaj   +1 more source

The Summer Daytime Meteor streams of 1949 and 1950: III. Computation of the Orbits [PDF]

, 1951
M. Almond
openalex   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Automatic discovery of cell types and microcircuitry from neural connectomics

eLife, 2015
Neural connectomics has begun producing massive amounts of data, necessitating new analysis methods to discover the biological and computational structure.
Eric Jonas, Konrad Kording
doaj   +1 more source

COMPUTATION OF ORBIT OF THE COMES OF SIRIUS [PDF]

, 1890
Alexander W. Roberts
openalex   +1 more source

Computability theory

, 2011
Short introduction to computability theory and computational complexity.
openaire   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Engineering Analysis of CMS Casing

Механика машин, механизмов и материалов, 2014
In the article the methodological requirements that are indispensable for the implementation of construction documents for the production and operation of developed structures and facilities in order to support the transition of products into commodities
L.V. Larchenkov, O.N. Protasenia, I.O. Protasenia   +2 more
doaj  

Art and Language After AI

Technophany
By ingesting a vast corpus of source material, generative deep learning models are capable of encoding multi-modal data into a shared embedding space, producing synthetic outputs which cannot be decomposed into their constituent parts.
Anil Bawa-Cavia
doaj   +1 more source