Results 61 to 70 of about 2,939,429 (324)
A framework for the local information dynamics of distributed computation in complex systems
, 2013 The nature of distributed computation has often been described in terms of the component operations of universal computation: information storage, transfer and modification.
A. Wuensche +62 more
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Frontiers in Computational NeuroscienceThis paper proposes a new theoretical framework for understanding time perception centered on information processing in the brain. We introduce the concept of “perceptual time” as distinct from inertial clock time and develop a model relating perceptual ...
Nicholas Jordan Wagter
doaj +1 more source
A Biologically-Based Computational Approach to Drug Repurposing for Anthrax Infection
Toxins, 2017 Developing drugs to treat the toxic effects of lethal toxin (LT) and edema toxin (ET) produced by B. anthracis is of global interest. We utilized a computational approach to score 474 drugs/compounds for their ability to reverse the toxic effects of ...
Jane P. F. Bai +2 more
doaj +1 more source
Optimal Embedding of Functions for In-Network Computation: Complexity Analysis and Algorithms
, 2015 We consider optimal distributed computation of a given function of distributed data. The input (data) nodes and the sink node that receives the function form a connected network that is described by an undirected weighted network graph.
Limaye, Nutan +2 more
core +1 more source
Computational geometry and discrete computations [PDF]
, 1996 In this paper we describe some problems arising in practical implementation of algorithms from computational geometry. Going to robust algorithms needs to solve issues such as rounding errors and degeneracies. Most of the problems are closely related to the incompatibility between on one side algorithms designed for continuous data and on the other ...
openaire +4 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
SoK: Delegated Security in the Internet of Things
Future InternetThe increased use of electronic devices in the Internet of Things (IoT) leads not only to an improved comfort of living but also to an increased risk of attacks. IoT security has thus become an important research field.
Emiliia Geloczi +3 more
doaj +1 more source