Results 71 to 80 of about 3,148,089 (334)
Computational geometry and discrete computations [PDF]
, 1996 In this paper we describe some problems arising in practical implementation of algorithms from computational geometry. Going to robust algorithms needs to solve issues such as rounding errors and degeneracies. Most of the problems are closely related to the incompatibility between on one side algorithms designed for continuous data and on the other ...
openaire +4 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Sinc-Approximations of Fractional Operators: A Computing Approach
Mathematics, 2015 We discuss a new approach to represent fractional operators by Sinc approximation using convolution integrals. A spin off of the convolution representation is an effective inverse Laplace transform.
Gerd Baumann, Frank Stenger
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Urban-Tissue Optimization through Evolutionary Computation
Mathematics, 2018 The experiments analyzed in this paper focus their research on the use of Evolutionary Computation (EC) applied to a parametrized urban tissue. Through the application of EC, it is possible to develop a design under a single model that addresses multiple
Diego Navarro-Mateu +2 more
doaj +1 more source
Bacteria as computers making computers [PDF]
FEMS Microbiology Reviews, 2009 Various efforts to integrate biological knowledge into networks of interactions have produced a lively microbial systems biology. Putting molecular biology and computer sciences in perspective, we review another trend in systems biology, in which recursivity and information replace the usual concepts of differential equations, feedback and feedforward ...
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2012 Fractional power computation of matrix is represented. Numerical calculations for ordinary differential equation and its fraction analog is done. Results are compared with Grunvald – Letnikov operator.
Ilyin, I.A. +2 more
doaj +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Modern econometrics: Structuring delivery and assessment
Cogent Economics & Finance, 2016 This paper provides a discussion of a recently introduced final-year econometrics module designed to capture methodological debates, advances in technology and increased data availability via a structure emphasising the practical nature of econometrics ...
Steve Cook
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