Results 71 to 80 of about 633,057 (286)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Conducting Web-Based Experiments for Numerical Cognition Research

Journal of Cognition, 2019
It is becoming increasingly popular and straightforward to collect data in cognitive psychology through web-based studies. In this paper, I review issues around web-based data collection for the purpose of numerical cognition research.
Arnold R. Kochari
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Optimizing Memory Efficiency for Convolution Kernels on Kepler GPUs

, 2017
Convolution is a fundamental operation in many applications, such as computer vision, natural language processing, image processing, etc. Recent successes of convolutional neural networks in various deep learning applications put even higher demand on ...
Chen, Danny Z., Chen, Jianxu, Chen, Xiaoming, Hu, Xiaobo Sharon   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The phenomenology of Deep Brain Stimulation-induced changes in OCD: An enactive affordance-based model

Frontiers in Human Neuroscience, 2013
People suffering from Obsessive-Compulsive Disorder (OCD) do things they do not want to do, and/or they think things they do not want to think. In about 10 percent of OCD patients, none of the available treatment options is effective.
Sanneke ede Haan, Erik eRietveld, Erik eRietveld, Erik eRietveld, Martin eStokhof, Damiaan eDenys, Damiaan eDenys   +6 more
doaj   +1 more source

An experimental study on performance portability of OpenCL kernels [PDF]

, 2010
Accelerator processors allow energy-efficient computation at high performance, especially for computationintensive applications. There exists a plethora of different accelerator architectures, such as GPUs and the Cell Broadband Engine.
D'Haene, Joris, De Bosschere, Koen, Rul, Sean, Vandierendonck, Hans   +3 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Quantized Detector Networks: A review of recent developments

, 2007
QDN (quantized detector networks) is a description of quantum processes in which the principal focus is on observers and their apparatus, rather than on states of SUOs (systems under observation).
Bjorken J. D., Bollinger J. J., Born M., Brandt H. E., Deutsch D., Eakins J., Eden R. J., Feynman R. P., Feynman R. P., G. JAROSZKIEWICZ, Jaroszkiewicz G., Peres A., Planck M., Schrodinger E., Schwinger J., von Neumann J., Zurek W. H.   +16 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source