Results 31 to 40 of about 1,973,231 (200)

A plea for neutral comparison studies in computational sciences [PDF]

, 2012
In computational science literature including, e.g., bioinformatics, computational statistics or machine learning, most published articles are devoted to the development of "new methods", while comparison studies are generally appreciated by ...
Manuel J. A. Eugster (406561), Eugster, Manuel J. A., Sabine Lauer, Manuel J. A. Eugster, Boulesteix, Anne-Laure, Manuel J A Eugster, Anne-Laure Boulesteix (401653), Eugster, Manuel J A, Eugster Manuel J. A., Anne-Laure Boulesteix, Lauer Sabine, Boulesteix Anne-Laure, Sabine Lauer (406560), Lauer, Sabine   +13 more
core   +2 more sources

Synchrony of biomarker variability indicates a critical transition: Application to mortality prediction in hemodialysis

iScience, 2022
Summary: Critical transition theory suggests that complex systems should experience increased temporal variability just before abrupt state changes. We tested this hypothesis in 763 patients on long-term hemodialysis, using 11 biomarkers collected every ...
Alan A. Cohen, Diana L. Leung, Véronique Legault, Dominique Gravel, F. Guillaume Blanchet, Anne-Marie Côté, Tamàs Fülöp, Juhong Lee, Frédérik Dufour, Mingxin Liu, Yuichi Nakazato   +10 more
doaj   +1 more source

A graph-based representation of Gene Expression profiles in DNA microarrays [PDF]

, 2008
This paper proposes a new and very flexible data model, called gene expression graph (GEG), for genes expression analysis and classification. Three features differentiate GEGs from other available microarray data representation structures: (i) the memory
A. Benso, Politano, Gianfranco Michele Maria, Benso, Alfredo, Sterpone, Luca, G. Politano, S. Di Carlo, L. Sterpone, Di Carlo, Stefano   +7 more
core   +1 more source

Origins and characterization of variants shared between databases of somatic and germline human mutations

BMC Bioinformatics, 2020
Background Mutations arise in the human genome in two major settings: the germline and the soma. These settings involve different inheritance patterns, time scales, chromatin structures, and environmental exposures, all of which impact the resulting ...
William Meyerson, John Leisman, Fabio C. P. Navarro, Mark Gerstein   +3 more
doaj   +1 more source

DiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring

BMC Bioinformatics, 2020
Background During transcription, numerous transcription factors (TFs) bind to targets in a highly coordinated manner to control the gene expression. Alterations in groups of TF-binding profiles (i.e.
Jing Zhang, Jason Liu, Donghoon Lee, Shaoke Lou, Zhanlin Chen, Gamze Gürsoy, Mark Gerstein   +6 more
doaj   +1 more source

Comprehensive enhancer-target gene assignments improve gene set level interpretation of genome-wide regulatory data

Genome Biology, 2022
Background Revealing the gene targets of distal regulatory elements is challenging yet critical for interpreting regulome data. Experiment-derived enhancer-gene links are restricted to a small set of enhancers and/or cell types, while the accuracy of ...
Tingting Qin, Christopher Lee, Shiting Li, Raymond G. Cavalcante, Peter Orchard, Heming Yao, Hanrui Zhang, Shuze Wang, Snehal Patil, Alan P. Boyle, Maureen A. Sartor   +10 more
doaj   +1 more source

Chromosome–nuclear envelope attachments affect interphase chromosome territories and entanglement

Epigenetics & Chromatin, 2018
Background It is well recognized that the interphase chromatin of higher eukaryotes folds into non-random configurations forming territories within the nucleus.
Nicholas Allen Kinney, Igor V. Sharakhov, Alexey V. Onufriev   +2 more
doaj   +1 more source

Highlighting computations in bioscience and bioinformatics: review of the Symposium of Computations in Bioinformatics and Bioscience (SCBB07) [PDF]

BMC Bioinformatics, 2008
The Second Symposium on Computations in Bioinformatics and Bioscience (SCBB07) was held in Iowa City, Iowa, USA, on August 13-15, 2007. This annual event attracted dozens of bioinformatics professionals and students, who are interested in solving emerging computational problems in bioscience, from China, Japan, Taiwan and the United States.
Guoqing Lu, Jun Ni
openaire   +2 more sources

Detecting the Molecular System Signatures of Idiopathic Pulmonary Fibrosis through Integrated Genomic Analysis

Scientific Reports, 2017
Idiopathic Pulmonary Fibrosis (IPF) is an incurable progressive fibrotic disease of the lungs. We currently lack a systematic understanding of IPF biology and a systems approach may offer new therapeutic insights. Here, for the first time, a large volume
Indu Gangwar, Nitesh Kumar Sharma, Ganesh Panzade, Supriya Awasthi, Anurag Agrawal, Ravi Shankar   +5 more
doaj   +1 more source

Computational identification of significant immunogenic epitopes of the putative outer membrane proteins from Mycobacterium tuberculosis

Journal of Genetic Engineering and Biotechnology, 2021
Novel vaccines are required to effectively combat the epidemic spread of tuberculosis. Using in silico approaches, this study focuses on prediction of potential B cell and T cell binding immunogenic epitopes for 30 putative outer membrane proteins of Mtb.
Shobana Sundar, Lokesh Thangamani, Shanmughavel Piramanayagam   +2 more
doaj   +1 more source