Results 101 to 110 of about 1,402,894 (317)

Computational Complexity of Simple P Systems [PDF]

, 2008
We introduce a new class of membrane systems called simple P systems, and study its computational complexity using the classical theory. We start by presenting the knapsack problem and analyzing its space and time complexities.
Ciobanu, Gabriel, Resios, Andreas
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A novel perturbation based compression complexity measure for networks

Heliyon, 2019
Measuring complexity of brain networks in the form of integrated information is a leading approach towards building a fundamental theory of consciousness.
Mohit Virmani, Nithin Nagaraj
doaj   +1 more source

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Two-Dimensional Direction-of-Arrival Fast Estimation of Multiple Signals with Matrix Completion Theory in Coprime Planar Array

Sensors, 2018
In estimating the two-dimensional (2D) direction-of-arrival (DOA) using a coprime planar array, the main issues are the high complexity of spectral peak search and the limited degree of freedom imposed by the number of sensors.
Haiyun Xu, Yankui Zhang, Bin Ba, Daming Wang, Xiangzhi Li   +4 more
doaj   +1 more source

Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi‐domain function and disability.
Chen Hu, Jiyeon Son, Lindsay McAlpine, Elizabeth L. S. Walker, Megan Dahl, Emily Song, Sugeidy Ferreira Brito, Katelyn Kavak, Kaho Onomichi, Amit Bar‐Or, Christopher Perrone, Claire S. Riley, Bianca Weinstock‐Guttman, Philip L. De Jager, Erin E. Longbrake, Zongqi Xia   +15 more
wiley   +1 more source

Altered Dynamic Functional Network Connectivity in Post‐Stroke Aphasia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Previous studies examining post‐stroke aphasia (PSA) patients via resting‐state functional magnetic resonance imaging (rs‐fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients ...
Guihua Xu, Yongsheng Wu, Junyu Qu, Rui Zhu, Wenwen Xu, Jiaxiang Xin, Dawei Wang   +6 more
wiley   +1 more source

Time-memory trade-offs for index calculus in genus 3

Journal of Mathematical Cryptology, 2015
In this paper, we present a variant of Diem's O˜(q)${\widetilde{O}(q)}$ index calculus algorithm to attack the discrete logarithm problem (DLP) in Jacobians of genus 3 non-hyperelliptic curves over a finite field 𝔽q.
Laine Kim, Lauter Kristin
doaj   +1 more source

A minimally-intrusive fully 3D separated plate formulation in computational structural mechanics

Advanced Modeling and Simulation in Engineering Sciences, 2019
Most of mechanical systems and complex structures exhibit plate and shell components. Therefore, 2D simulation, based on plate and shell theory, appears as an appealing choice in structural analysis as it allows reducing the computational complexity ...
Giacomo Quaranta, Mustapha Ziane, Eberhard Haug, Jean-Louis Duval, Francisco Chinesta   +4 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source