Results 121 to 130 of about 1,379,053 (353)

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

FEBS Open Bio, EarlyView.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang, Yoshitaka Nakajima, Masae Kurobe, Tsutomu Nakamura, Tomoki Himiyama, Yoshiaki Nishiya   +5 more
wiley   +1 more source

Bridging the gap between complexity science and clinical practice by formalizing idiographic theories: a computational model of functional analysis [PDF]

, 2020
Julian Burger, Date C. van der Veen, Donald J. Robinaugh, Rick Quax, Harriëtte Riese, Robert A. Schoevers, Sacha Epskamp   +6 more
openalex   +1 more source

Canonical density matrix perturbation theory

, 2015
Density matrix perturbation theory [Niklasson and Challacombe, Phys. Rev. Lett. 92, 193001 (2004)] is generalized to canonical (NVT) free energy ensembles in tight-binding, Hartree-Fock or Kohn-Sham density functional theory. The canonical density matrix
Cawkwell, Marc J., Niklasson, Anders M. N., Rubensson, Emanuel H., Rudberg, Elias   +3 more
core   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

A novel perturbation based compression complexity measure for networks

Heliyon, 2019
Measuring complexity of brain networks in the form of integrated information is a leading approach towards building a fundamental theory of consciousness.
Mohit Virmani, Nithin Nagaraj
doaj   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Two-Dimensional Direction-of-Arrival Fast Estimation of Multiple Signals with Matrix Completion Theory in Coprime Planar Array

Sensors, 2018
In estimating the two-dimensional (2D) direction-of-arrival (DOA) using a coprime planar array, the main issues are the high complexity of spectral peak search and the limited degree of freedom imposed by the number of sensors.
Haiyun Xu, Yankui Zhang, Bin Ba, Daming Wang, Xiangzhi Li   +4 more
doaj   +1 more source

Compilability of Abduction

, 2002
Abduction is one of the most important forms of reasoning; it has been successfully applied to several practical problems such as diagnosis. In this paper we investigate whether the computational complexity of abduction can be reduced by an appropriate ...
Bylander T., Cadoli M., Cialdea Mayer M., Darwiche A., Del Val A., Del Val A., Eiter T., Eiter T., Flach P., Johnson D. S., Levesque H. J., Marco Schaerf, Paolo Liberatore, Reiter R., Selman B.   +14 more
core   +1 more source

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Computational Complexity of Simple P Systems [PDF]

, 2008
We introduce a new class of membrane systems called simple P systems, and study its computational complexity using the classical theory. We start by presenting the knapsack problem and analyzing its space and time complexities.
Ciobanu, Gabriel, Resios, Andreas
core