Results 61 to 70 of about 828,043 (333)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Toward A Better Understanding of Perceived Complexity in Music: A Commentary on Eerola (2016)
Empirical Musicology Review, 2016 Eerola (2016) evaluates models of musical complexity based on expectancy violation and information theory. This commentary notes the deep relationship between these two phenomena, and argues for a more active partnership between computational and ...
Elizabeth Hellmuth Margulis
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Note on stability and holographic subregion complexity
European Physical Journal C: Particles and Fields, 2022 We study holographic subregion complexity in a spatially anisotropic field theory, which expresses a confinement-deconfinement phase transition. Its holographic dual is a five-dimensional anisotropic holographic model characterized by a Van der Waals ...
Mohammad Ali-Akbari, Mahsa Lezgi
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Volume and complexity for Warped AdS black holes
Journal of High Energy Physics, 2018 We study the Complexity=Volume conjecture for Warped AdS3 black holes. We compute the spatial volume of the Einstein-Rosen bridge and we find that its growth rate is proportional to the Hawking temperature times the Bekenstein-Hawking entropy.
Roberto Auzzi +2 more
doaj +1 more source
Interactions of computational complexity theory and mathematics
, 2023 $ $[This paper is a (self contained) chapter in a new book, Mathematics and Computation, whose draft is available on my homepage at https://www.math.ias.edu/avi/book ]. We survey some concrete interaction areas between computational complexity theory and different fields of mathematics.
openaire +2 more sources
Relativistic Computers and Non-uniform Complexity Theory [PDF]
, 2002 Recent research in theoretical physics on 'Malament-Hogarth space-times' indicates that so-called relativistic computers can be conceived that can carry out certain classically undecidable queries in finite time. We observe that the relativistic Turing machines which model these computations recognize precisely the ?2-sets of the Arithmetical Hierarchy.
van Leeuwen, J., Wiedermann, J.
openaire +3 more sources