Results 61 to 70 of about 1,402,894 (317)
Computational Complexity as an Ultimate Constraint on Evolution
Genetics, 2019 Experiments show that evolutionary fitness landscapes can have a rich combinatorial structure due to epistasis. For some landscapes, this structure can produce a computational constraint that prevents evolution from finding local fitness optima—thus ...
Artem Kaznatcheev
semanticscholar +1 more source
A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer
Molecular Oncology, EarlyView.Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla +15 more
wiley +1 more source
50 Years of Computational Complexity: Hao Wang and the Theory of Computation [PDF]
, 2022 Nick Zhang
openalex +1 more source
Uncertainty and computational complexity
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2018 Modern theories of decision-making typically model uncertainty about decision options using the tools of probability theory. This is exemplified by the Savage framework, the most popular framework in decision-making research.
P. Bossaerts +2 more
semanticscholar +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Toward A Better Understanding of Perceived Complexity in Music: A Commentary on Eerola (2016)
Empirical Musicology Review, 2016 Eerola (2016) evaluates models of musical complexity based on expectancy violation and information theory. This commentary notes the deep relationship between these two phenomena, and argues for a more active partnership between computational and ...
Elizabeth Hellmuth Margulis
doaj +1 more source
Note on stability and holographic subregion complexity
European Physical Journal C: Particles and Fields, 2022 We study holographic subregion complexity in a spatially anisotropic field theory, which expresses a confinement-deconfinement phase transition. Its holographic dual is a five-dimensional anisotropic holographic model characterized by a Van der Waals ...
Mohammad Ali-Akbari, Mahsa Lezgi
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Volume and complexity for Warped AdS black holes
Journal of High Energy Physics, 2018 We study the Complexity=Volume conjecture for Warped AdS3 black holes. We compute the spatial volume of the Einstein-Rosen bridge and we find that its growth rate is proportional to the Hawking temperature times the Bekenstein-Hawking entropy.
Roberto Auzzi +2 more
doaj +1 more source