Results 71 to 80 of about 1,379,053 (353)

Computational Complexity

open access: yesEntropy, 2017
Complex systems (CS) involve many elements that interact at different scales in time and space. The challenges in modeling CS led to the development of novel computational tools with applications in a wide range of scientific areas.
J. A. Tenreiro Machado   +1 more
doaj   +1 more source

The Complexity of Mental Integer Addition

open access: yesJournal of Numerical Cognition, 2020
An important paradigm in modeling the complexity of mathematical tasks relies on computational complexity theory, in which complexity is measured through the resources (time, space) taken by a Turing machine to carry out the task.
Stefan Buijsman, Markus Pantsar
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Computational Complexity as an Ultimate Constraint on Evolution

open access: yesGenetics, 2019
Experiments show that evolutionary fitness landscapes can have a rich combinatorial structure due to epistasis. For some landscapes, this structure can produce a computational constraint that prevents evolution from finding local fitness optima—thus ...
Artem Kaznatcheev
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

Statistical Complexity Analysis of Turing Machine tapes with Fixed Algorithmic Complexity Using the Best-Order Markov Model

open access: yesEntropy, 2020
Sources that generate symbolic sequences with algorithmic nature may differ in statistical complexity because they create structures that follow algorithmic schemes, rather than generating symbols from a probabilistic function assuming independence.
Jorge M. Silva   +3 more
doaj   +1 more source

Uncertainty and computational complexity

open access: yesPhilosophical Transactions of the Royal Society of London. Biological Sciences, 2018
Modern theories of decision-making typically model uncertainty about decision options using the tools of probability theory. This is exemplified by the Savage framework, the most popular framework in decision-making research.
P. Bossaerts   +2 more
semanticscholar   +1 more source

A Computable Economist’s Perspective on Computational Complexity [PDF]

open access: yes, 2007
A computable economist's view of the world of computational complexity theory is described. This means the model of computation underpinning theories of computational complexity plays a central role.
Vela Velupillai, K.
core  

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

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