Results 101 to 110 of about 2,147,957 (198)

Reliability-based design optimization of shells with uncertain geometry using adaptive Kriging metamodels

, 2017
Optimal design under uncertainty has gained much attention in the past ten years due to the ever increasing need for manufacturers to build robust systems at the lowest cost.
Bourinet, J. -M., Dubourg, V., Sudret, B.   +2 more
core  

Influenza B Virus Vaccine Innovation through Computational Design

Pathogens
As respiratory pathogens, influenza B viruses (IBVs) cause a significant socioeconomic burden each year. Vaccine and antiviral development for influenza viruses has historically viewed IBVs as a secondary concern to influenza A viruses (IAVs) due to ...
Matthew J. Pekarek, Eric A. Weaver
doaj   +1 more source

A CAD-Integrated Framework for Dynamic Structural Topology Optimisation via Visual Programming

Computation
Structural Topology Optimisation (STO) plays a critical role in computational engineering, enabling the creation of material-efficient, performance-driven structures.
Laura Sardone, Stefanos Sotiropoulos, Alessandra Fiore   +2 more
doaj   +1 more source

Cancer immunogenomics: Computational neoantigen identification and vaccine design [PDF]

, 2016
Coffman, Adam, Graubert, Aaron, Griffith, Malachi, Griffith, Obi L, Hundal, Jasreet, Kiwala, Susanna, Mardis, Elaine R, McMichael, Joshua, Miller, Christopher J, Walker, Jason   +9 more
core   +2 more sources

Sustainable Co-Habitation Housing Design: A Computational Approach for Addressing Biodiversity Threats in the Galapagos Islands

Architecture
This study explores sustainable housing solutions for urban areas in the Galapagos Islands, aiming to balance human needs with ecosystem preservation by fostering co-habitation between local communities and native species.
Gianfranco Maiorano, Natalia Juca Freire, Rapas Teparaksa, Pinak Dilip Bhapkar, Elif Erdine, Milad Showkatbakhsh   +5 more
doaj   +1 more source

Computational Design of Phosphotriesterase Improves V‐Agent Degradation Efficiency

ChemistryOpen
Organophosphates (OPs) are a class of neurotoxic acetylcholinesterase inhibitors including widely used pesticides as well as nerve agents such as VX and VR.
Jacob Kronenberg, Stanley Chu, Andrew Olsen, Dustin Britton, Leif Halvorsen, Shengbo Guo, Ashwitha Lakshmi, Jason Chen, Maria Jinu Kulapurathazhe, Cetara A. Baker, Benjamin C. Wadsworth, Cynthia J. Van Acker, John G. Lehman III, Tamara C. Otto, P. Douglas Renfrew, Richard Bonneau, Jin Kim Montclare   +16 more
doaj   +1 more source

Computational design of metallohydrolases. [PDF]

Nature
Kim D, Woodbury SM, Ahern W, Tischer D, Kang A, Joyce E, Bera AK, Hanikel N, Salike S, Krishna R, Yim J, Pellock SJ, Lauko A, Kalvet I, Hilvert D, Baker D.   +15 more
europepmc   +1 more source

Computational design of generalist cyclopropanases with stereodivergent selectivity. [PDF]

Nat Commun
Shen Z, Siriboe MG, Ren X, Dayananda T, Jenkins JL, Khare SD, Fasan R.   +6 more
europepmc   +1 more source

Computational design of functional random heteropolymers through atomistic simulations. [PDF]

PLoS One
Jin T, Lung CS, Xu T, Coley CW, Alexander-Katz A.   +4 more
europepmc   +1 more source

Computational design of dynamic biosensors for emerging synthetic opioids. [PDF]

Nat Commun
Leonard AC, Lenert-Mondou C, Chayer R, Swift S, Baumer ZT, Delaney R, Friedman AJ, Robertson NR, Seder N, Wells J, Whitmore LM, Cutler SR, Shirts MR, Wheeldon I, Whitehead TA.   +14 more
europepmc   +1 more source