Results 241 to 250 of about 17,712,238 (346)

Computational design of allulose-responsive biosensor toolbox for auto-inducible protein expression and CRISPRi mediated dynamic metabolic regulation. [PDF]

Nat Commun
Dong Q, Chen P, Guo Z, Wei H, Zeng Y, Zhang J, Men Y, Liu W, Sun Y, Yang J.   +9 more
europepmc   +1 more source

MOFs and COFs in Electronics: Bridging the Gap between Intrinsic Properties and Measured Performance

Advanced Functional Materials, EarlyView.
Metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) hold promise for advanced electronics. However, discrepancies in reported electrical conductivities highlight the importance of measurement methodologies. This review explores intrinsic charge transport mechanisms and extrinsic factors influencing performance, and critically ...
Jonas F. Pöhls, R. Thomas Weitz
wiley   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Computational design of a multiepitope vaccine targeting VP1 and VP2 capsid proteins of simian virus 40 (SV40) for enhanced immune activation. [PDF]

Open Med (Wars)
Naveed M, Asim M, Aziz T, Amjad S, Majeed MN, Jamal SB, El Hadi Mohamed RA, Alwethaynani MS, Al-Joufi FA, Fallatah D, Alkhatib SN.   +10 more
europepmc   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Computational design of an improved photoswitchable psychedelic based on light absorption, membrane permeation and protein binding. [PDF]

Phys Chem Chem Phys
Palmisano VF, Agnorelli C, Faraji S, Nogueira JJ.   +3 more
europepmc   +1 more source

A Termite‐Inspired Alternative to Cement

Advanced Functional Materials, EarlyView.
A termite‐inspired composite of clay, cellulose, and lignin forms a dense fibrous network with concrete‐like strength (32 MPa) and superior elasticity, processed at ambient temperature. Abstract Clay combined with organic materials is used by termites as a strong and durable construction material for their mounds with minimal environmental impact. Here,
Oren Regev, Peter Fratzl, Emeline Raguin, Markus Antonietti   +3 more
wiley   +1 more source

Computational Design of Potentially Multifunctional Antimicrobial Peptide Candidates via a Hybrid Generative Model. [PDF]

Int J Mol Sci
Ying F, Go W, Li Z, Ouyang C, Phaphuangwittayakul A, Dhuny R.   +5 more
europepmc   +1 more source