Results 31 to 40 of about 233,268 (268)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The mutational signatures of formalin fixation on the human genome

Nature Communications, 2022
Many archived tumour samples are stored as formalin-fixed and paraffin-embedded (FFPE) blocks, but this treatment can impact downstream genomics analyses.
Qingli Guo, Eszter Lakatos, Ibrahim Al Bakir, Kit Curtius, Trevor A. Graham, Ville Mustonen   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mechanistic phylodynamic models do not provide conclusive evidence that non-avian dinosaurs were in decline before their final extinction

Cambridge Prisms: Extinction
Phylodynamic models can be used to estimate diversification trajectories from time-calibrated phylogenies. Here we apply two such models to phylogenies of non-avian dinosaurs, a clade whose evolutionary history has been widely debated.
Bethany J. Allen, Maria V. Volkova Oliveira, Tanja Stadler, Timothy G. Vaughan, Rachel C. M. Warnock   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Population Genetics Meets Ecology: A Guide to Individual‐Based Simulations in Continuous Landscapes

Ecology and Evolution
Individual‐based simulation has become an increasingly crucial tool for many fields of population biology. However, continuous geography is important to many applications, and implementing realistic and stable simulations in continuous space presents a ...
Elizabeth T. Chevy, Jiseon Min, Victoria Caudill, Samuel E. Champer, Benjamin C. Haller, Clara T. Rehmann, Chris C. R. Smith, Silas Tittes, Philipp W. Messer, Andrew D. Kern, Sohini Ramachandran, Peter L. Ralph   +11 more
doaj   +1 more source

Correction to: FastMM: an efficient toolbox for personalized constraint-based metabolic modeling

BMC Bioinformatics, 2020
An amendment to this paper has been published and can be accessed via the original article.
Gong-Hua Li, Shaoxing Dai, Feifei Han, Wenxing Li, Jingfei Huang, Wenzhong Xiao   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Ancient hybridization fuels rapid cichlid fish adaptive radiations

Nature Communications, 2017
Cichlids underwent a rapid diversification in the Lake Victoria region, expanding to more than 700 species within 150,000 years. Here, Meier and colleagues show that an ancient hybridization between two divergent cichlid lineages generated high genetic ...
Joana I. Meier, David A. Marques, Salome Mwaiko, Catherine E. Wagner, Laurent Excoffier, Ole Seehausen   +5 more
doaj   +1 more source

Comparative morphology and evolution of the cnidosac in Cladobranchia (Gastropoda: Heterobranchia: Nudibranchia)

Frontiers in Zoology, 2018
Background A number of shelled and shell-less gastropods are known to use multiple defensive mechanisms, including internally generated or externally obtained biochemically active compounds and structures.
Jessica A. Goodheart, Sabrina Bleidißel, Dorothee Schillo, Ellen E. Strong, Daniel L. Ayres, Angelika Preisfeld, Allen G. Collins, Michael P. Cummings, Heike Wägele   +8 more
doaj   +1 more source