Results 41 to 50 of about 393,349 (304)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Four PPPPerspectives on Computational Creativity [PDF]

, 2015
From what perspective should creativity of a system be considered? Are we interested in the creativity of the system’s out- put? The creativity of the system itself? Or of its creative processes? Creativity as measured by internal features or by external
Jordanous, Anna
core  

Experiments with computers. [PDF]

BMJ, 1977
T R, Kapur, M, Clarke, P J, Leopard
  +12 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Optimization of Thermal Insulation Parameters for Vertical Perimeters in Buildings with Single-Layer Walls

Buildings
This article presents the results of a study on the impact of selected parameters of a building’s ground-floor zone (the junction of the external and foundation walls, the ground floor slab, and the ground itself) on the temperature field within the ...
Walery Jezierski, Paula Szczepaniak, Cezary Leszczyński   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Performance Increase of the Digital Fourier Filter in Measuring Bodies of Microprocessor Protections

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика
A technique for constructing a digital filter based on the discrete Fourier transform as part of microprocessor protections for electrical installations which is characterized by increased performance in the transient mode of setting its output signal is
V. Yu. Rumiantsev, Yu. V. Rumiantsev, F. A. Romaniuk, A. A. Dziaruhina   +3 more
doaj   +1 more source

Integrated Design of a Supermarket Refrigeration System by Means of Experimental Design Adapted to Computational Problems

Algorithms, 2022
In this paper, an integrated design of a supermarket refrigeration system has been used to obtain a process with better operability. It is formulated as a multi-objective optimization problem where control performance is evaluated by six indices and the ...
Daniel Sarabia, María Cruz Ortiz, Luis Antonio Sarabia   +2 more
doaj   +1 more source