Results 81 to 90 of about 393,349 (304)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Agent-Based Computational Modeling And Macroeconomics [PDF]

Agent-based Computational Economics (ACE) is the computational study of economic processes modeled as dynamic systems of interacting agents. This essay discusses the potential use of ACE modeling tools for the study of macroeconomic systems.
Tesfatsion, Leigh
core  

Computational Cognitive Models of Summarization Assessment Skills [PDF]

, 2005
This paper presents a general computational cognitive model of the way a summary is assessed by teachers. It is based on models of two subprocesses: determining the importance of sentences and guessing the cognitive rules that the student may have used ...
Lamaire, Benoit, Mandin, Sonia, Denhière, Guy, Dessus, Philippe, Lemaire, Benoit   +4 more
core  

Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study

, 2013
Circular Dichroism (CD) spectroscopy is a powerful method for investigating conformational changes in proteins and therefore has numerous applications in structural and molecular biology. Here a computational investigation of the CD spectrum of the Human
Uno Carlsson, Kia Balali-Mood (210078), Karabencheva-Christova, Tatyana G, Balali-Mood Kia, Gary W. Black (382116), Black Gary W., Carlsson, Uno,, Kia Balali-Mood, Christov, Christo Z., Carlsson, Uno, Balali-Mood, Kia,, Christo Z Christov, Christov, Christo, Christov Christo Z., Karabencheva-Christova, Tatyana G,, Tatyana G. Karabencheva-Christova (382114), Uno Carlsson (382115), Black, Gary W., Karabencheva-Christova, Tatyana, Christo Z. Christov (382117), Tatyana G Karabencheva-Christova, Balali-Mood, Kia, Karabencheva-Christova Tatyana G., Carlsson Uno, Black, Gary W.,, Gary W Black, Black, Gary, Christov, Christo Z.,   +27 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Protein name for each signature used in the computational experiment.

, 2013
Protein name for each signature used in the computational experiment.
Pablo Moscato (95573), Martín Gómez Ravetti (95572)   +1 more
core   +1 more source

Optimization using surrogate models and partially converged computational fluid dynamics simulations [PDF]

, 2006
Efficient methods for global aerodynamic optimization using computational fluid dynamics simulations should aim to reduce both the time taken to evaluate design concepts and the number of evaluations needed for optimization.
Alexander I.J. Forrester, Andy J. Keane, Keane, A.J., Forrester, A.I.J., Bressloff, N.W., Neil W. Bressloff   +5 more
core   +1 more source

Computer Experiments

, 2022
Here we solve the following combinatorial problem involving the inclusion-exclusion principle and Stirling numbers. In a series of 30 experiments, a computer randomly generates one of the numbers 1, ..., 10. What is the probability that each number occurs at least once?
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Agent-Based Computational Economics: A Constructive Approach to Economic Theory [PDF]

This chapter explores the potential advantages and disadvantages of Agent-based Computational Economics (ACE) for the study of economic systems. General points are concretely illustrated using an ACE model of a two-sector decentralized market economy ...
Tesfatsion, Leigh
core