Results 111 to 120 of about 67,243 (217)

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

open access: yesAdvanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang   +14 more
wiley   +1 more source

A Programmed DNA Dynamic Assembly‐Guided Molecular Amplifier for Authentic Information Decryption

open access: yesAdvanced Science, EarlyView.
This study presents a DNA‐based constitutional dynamic network (CDN) with adaptive thresholds for secure information decryption. The system self‐calibrates output patterns, ensuring reproducibility and accuracy, and integrates molecular amplifiers for expanded message capacity and precise DNA sensing.
Ning Yang   +9 more
wiley   +1 more source

Epileptiform Activity and Seizure Risk Follow Long‐Term Non‐Linear Attractor Dynamics

open access: yesAdvanced Science, EarlyView.
This study leverages the HAVOK framework to model long‐term, nonlinear attractor dynamics underlying epileptiform activity and seizure risk in epilepsy patients. By identifying key forcing mechanisms driving chaotic transitions, the findings improve seizure risk forecasting over multi‐day cycles and provide a pathway for personalized, data‐driven ...
Richard E Rosch   +4 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

open access: yesAdvanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong   +20 more
wiley   +1 more source

A review of machine learning methods for imbalanced data challenges in chemistry. [PDF]

open access: yesChem Sci
Jiang J   +8 more
europepmc   +1 more source

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

open access: yesAdvanced Science, EarlyView.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li   +16 more
wiley   +1 more source

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