Results 41 to 50 of about 83,569 (221)
Order Reduction of the Chemical Master Equation via Balanced Realisation
, 2014 We consider a Markov process in continuous time with a finite number of discrete states. The time-dependent probabilities of being in any state of the Markov chain are governed by a set of ordinary differential equations, whose dimension might be large ...
Lopez-Caamal, Fernando +1 more
core +3 more sources
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, EarlyView.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
FireThis article discusses and compares approaches to the visualization of the danger zone formed as a result of spreading toxic substances during a fire at an industrial enterprise, to create predictive models and scenarios for evacuation and environmental ...
Yuri Matveev +3 more
doaj +1 more source
Technique(s) for Spike - Sorting [PDF]
, 2004 Spike-sorting techniques attempt to classify a series of noisy electrical waveforms according to the identity of the neurons that generated them. Existing techniques perform this classification ignoring several properties of actual neurons that can ...
Pouzat, Christophe
core +4 more sources
The Anatomical Record, EarlyView.Abstract The ray‐finned fishes include one out of every two species of living vertebrates on Earth and have an abundant fossil record stretching 380 million years into the past. The division of systematic knowledge of ray‐finned fishes between paleontologists working on extinct animals and neontologists studying extant species has obscured the ...
Jack Stack
wiley +1 more source
Efficient computational strategies for doubly intractable problems with applications to Bayesian social networks [PDF]
, 2014 Powerful ideas recently appeared in the literature are adjusted and combined to design improved samplers for Bayesian exponential random graph models. Different forms of adaptive Metropolis-Hastings proposals (vertical, horizontal and rectangular) are ...
Caimo, Alberto, Mira, Antonietta
core +2 more sources
SCoPE: An efficient method of Cosmological Parameter Estimation
, 2014 Markov Chain Monte Carlo (MCMC) sampler is widely used for cosmological parameter estimation from CMB and other data. However, due to the intrinsic serial nature of the MCMC sampler, convergence is often very slow.
Das, Santanu, Souradeep, Tarun
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng +6 more
wiley +1 more source
Driving Markov chain Monte Carlo with a dependent random stream [PDF]
, 2012 Markov chain Monte Carlo is a widely-used technique for generating a dependent sequence of samples from complex distributions. Conventionally, these methods require a source of independent random variates.
Elliott, Lloyd T., Murray, Iain
core
Regional Shopping Objectives in British Grocery Retail Transactions Using Segmented Topic Models
Applied Stochastic Models in Business and Industry, EarlyView.ABSTRACT Understanding the customer behaviours behind transactional data has high commercial value in the grocery retail industry. Customers generate millions of transactions every day, choosing and buying products to satisfy specific shopping needs.
Mariflor Vega Carrasco +4 more
wiley +1 more source