Results 81 to 90 of about 23,325 (286)

Methods for Uncertainty Quantification in Dictionary Matching to Advance Reliability of Quantitative MRI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Aims Purpose: Dictionary matching is a standard tool in quantitative MRI (qMRI), but typically lacks uncertainty quantification (UQ). This is critical when advanced reconstructions (e.g., compressed sensing, deep learning) introduce complex‐valued, spatially varying, and temporally correlated noise that violates standard assumptions of ...
Brian Toner, Ute Goerke, Eze Ahanonu, Kevin Johnson, Vibhas Deshpande, Holden H. Wu, Maria I. Altbach, Ali Bilgin   +7 more
wiley   +1 more source

A Novel Two‐Stage Flexible Flow Shop Batch Scheduling Model for Grinding Workshops

Naval Research Logistics (NRL), EarlyView.
ABSTRACT The growing need for data storage in data centers has increased the demand for mechanical hard disks due to their low cost and high reliability. Aluminum substrates are the most popular base plates for mechanical hard disks because of their high hardness and low cost.
Jun Xu, Xuanru Pan, Chao‐Bo Yan, Guo‐Qiang Fan, Zhixin Liu   +4 more
wiley   +1 more source

Improving Affordability and Accessibility for Socially‐Beneficial Services via Government Incentives

Naval Research Logistics (NRL), EarlyView.
ABSTRACT Many socially‐beneficial services, like dental care, suffer from a dual challenge: Low affordability for citizens and long waiting times due to insufficient provider capacity. We model a government's problem of designing subsidy policies to address this issue.
Xiaoyan Zhao, Venus Lo, Stephen Shum
wiley   +1 more source

Waves of range dynamics and gene flow characterize the biogeographic history of Litsea elongata, a dominant tree in East Asian evergreen broadleaved forests

PLANTS, PEOPLE, PLANET, EarlyView.
Evergreen broadleaved forests (EBLFs) represent an iconic vegetation type in subtropical montane East Asia, but they are experiencing intensifying anthropogenic pressure and increasing habitat fragmentation. Here, using a dominant and widespread tree species characteristic of East Asian EBLFs, we examine its phylogeographic history and evaluate what it
Sheng‐Yuan Qin, Richard H. Ree, Zheng‐Yu Zuo, Chih‐Chieh Yu, Shuang‐Xiu Xu, Jun Rong, Peng‐Fei Ma, De‐Zhu Li   +7 more
wiley   +1 more source

Computation of identity by descent probabilities conditional onDNA markers via a Monte Carlo Markov Chain method [PDF]

, 2000
Miguel P�rez-Enciso, L. Varona, Max F. Rothschild   +2 more
openalex   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou, Anne Auperin, Jôel Guigay, Sébastien Salas, Sebastien Benzekry   +4 more
wiley   +1 more source

Impact of Packaging and Recycling Systems on Material Recirculation: A Stage‐Decomposition Model

Packaging Technology and Science, EarlyView.
A system‐level view emerges from decomposing recycling into four stages (participation, collection, sorting and process yield), diagnosing constraints and targeting interventions. Cumulative equivalent uses (CEUs) quantify long‐term retention, revealing marginal improvements at high baselines generate disproportionately larger gains than low‐baseline ...
Diogo Figueirinhas, Daniel Hellström, Henrik Pålsson, Yulia Vakulenko   +3 more
wiley   +1 more source