Results 91 to 100 of about 388,706 (268)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
On Parallel Models of Computation [PDF]
, 2007 The emerging trend on multi-core chips is changing the technology landscape of computing system in the scale that has not been witnessed since the Intel microprocessor chip commissioned in early 1970s. However, the implication of this technology revolution is profound: its success can only be ensured if we can successfully (productively) implement ...
openaire +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Discover Applied SciencesThis study aims to investigate the mass and heat transmission in a magnetohydrodynamic micropolar fluid over a curved stretching sheet. It focuses on the combined effects of thermal radiation, chemical reaction and porosity via velocity, temperature ...
Bal Krishn Vaishnav +5 more
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Journal of Marine Science and EngineeringThe utilization of ocean wave energy through environmentally sustainable technologies plays a pivotal role in the transition toward renewable energy sources.
Rodrigo Costa Batista +4 more
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Journal of Mathematical Sciences, 2018 We state fundamental results of structural theory of computably separable models and consider applications of this theory to solution of some actual problems of the theory of effective linear orders and theoretical informatics.
Kasymov, N. Kh., Ibragimov, F. N.
openaire +3 more sources
A generalized Debye-Hückel theory of electrolyte solutions
AIP Advances, 2019 We propose a generalized Debye-Hückel (DH) theory by using a recent Poisson-Fermi model that accounts for the steric, correlation, and polarization effects of ions and water treated as nonuniform spheres with interstitial voids. The generalized DH theory
Jinn-Liang Liu, Chin-Lung Li
doaj +1 more source