Results 81 to 90 of about 771,325 (233)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Scientific Reports, 2021 Legged locomotion has evolved as the most common form of terrestrial locomotion. When the leg makes contact with a solid surface, muscles absorb some of the shock-wave accelerations (impacts) that propagate through the body.
Kasper B. Christensen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Local mixture models of exponential families [PDF]
, 2007 Exponential families are the workhorses of parametric modelling theory. One reason for their popularity is their associated inference theory, which is very clean, both from a theoretical and a computational point of view.
Anaya-Izquierdo, Karim, Marriott, Paul
core +5 more sources
Loss-of-Imprinting of HM13 Leads to Poor Prognosis in Clear Cell Renal Cell Carcinoma
BiomoleculesGenomic imprinting refers to the epigenetic silencing of one of both alleles in a parent-of-origin-specific manner, particularly in genes regulating growth and development.
Floris Voorthuijzen +4 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Architecture of Environmental Risk Modelling: for a faster and more robust response to natural disasters [PDF]
, 2014 Demands on the disaster response capacity of the European Union are likely to increase, as the impacts of disasters continue to grow both in size and frequency.
de Rigo, Daniele +2 more
core
Rheology effect determination of the heterogeneous rock massif on the stress-strain state of the breakage face geomechanical system [PDF]
, 2018 The purpose of this study is to determine the nature of influence of the rheological properties of the rocks on the results of computational experiments simulating the mine workings contour condition during the breakage face advance. To
Fomychov, Vadym +11 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Design and testing of a contra-rotating tidal current turbine [PDF]
, 2005 A contra-rotating marine current turbine has a number of attractive features: nearzero reactive torque on the support structure, near-zero swirl in the wake, and high relative inter-rotor rotational speeds.
Clarke, J. A. +3 more
core +4 more sources