Results 101 to 110 of about 2,962,605 (298)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A new method for voxelizing mesh phantoms through cross-sectional images

Brazilian Journal of Radiation Sciences
Exposure Computational Models (ECMs) utilize algorithms for ionizing radiation sources and Monte Carlo (MC) codes to simulate radiation transport, its interaction with matter, and to assess the energy deposited in volumes of interest (VOIs) represented ...
Raniele Costa de Matos dos Santos, Whoody Alem Wanderley Araripe Farias, José Wilson VIEIRA, Pedro Henrique Avelino de ANDRADE, Jefferson Melo Gonçalves PENA, Vanildo Júnior de Melo LIMA, Fernando Roberto de Andrad LIMA   +6 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Computational retrospective dosimetry with fortuitous dosimeters: An inter-laboratory comparison and evaluation of dose conversion coefficients

Nuclear Engineering and Technology
In large-scale radiological accidents, retrospective dose assessment is crucial for individuals without personal dosimeters. This study investigates the applicability of computational dosimetry and dose conversion coefficients (DCCs) using mobile phones ...
Min Chae Kim, Hyoungtaek Kim, Yoomi Choi, Sora Kim, Jungil Lee, Byung Il Min, Kyungsuk Suh, Jiyoon Kim, Hanjin Lee, Jeong Tae Lee, Hyungjoon Yu, Young-su Kim, Han Sung Kim, Chan Hyeong Kim   +13 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Dose coefficients of mesh-type reference Korean phantoms (MRKPs) for idealized external exposure geometries of photons and electrons

Nuclear Engineering and Technology
The present study produced Korean-specific dose coefficients for idealized external exposures to photons and electrons by performing Monte Carlo dose calculations with mesh-type reference Korean phantoms (MRKPs).
Sungho Moon, Chansoo Choi, Bangho Shin, Gahee Son, Haegin Han, Hyeonil Kim, Suhyeon Kim, Jaehyo Kim, Yumin Lee, Jong Hwi Jeong, Chan Hyeong Kim, Yeon Soo Yeom   +11 more
doaj   +1 more source

A new mini-navigation tool allows accurate component placement during anterior total hip arthroplasty. [PDF]

, 2018
Introduction: Computer-assisted navigation systems have been explored in total hip arthroplasty (THA) to improve component positioning. While these systems traditionally rely on anterior pelvic plane registration, variances in soft tissue thickness ...
Benson, Jessica R., Muir, Jeffrey M., Parvizi, Javad, MD   +2 more
core   +1 more source

Learned Primal-dual Reconstruction

, 2018
We propose the Learned Primal-Dual algorithm for tomographic reconstruction. The algorithm accounts for a (possibly non-linear) forward operator in a deep neural network by unrolling a proximal primal-dual optimization method, but where the proximal ...
Adler, Jonas, Öktem, Ozan
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source