Results 111 to 120 of about 2,962,605 (298)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A Novel Wearable Sensor for Measuring Respiration Continuously and in Real Time

Sensors
In this work, a flexible textile-based capacitive respiratory sensor, based on a capacitive sensor structure, that does not require direct skin contact is designed, optimised, and evaluated using both computational modelling and empirical measurements ...
Amjad Ali, Yang Wei, Yomna Elsaboni, Jack Tyson, Harry Akerman, Alexander I. R. Jackson, Rod Lane, Daniel Spencer, Neil M. White   +8 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Solving ill-posed inverse problems using iterative deep neural networks

, 2017
We propose a partially learned approach for the solution of ill posed inverse problems with not necessarily linear forward operators. The method builds on ideas from classical regularization theory and recent advances in deep learning to perform learning
Adler, Jonas, Öktem, Ozan
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Dose coefficients for ICRP pediatric mesh-type reference computational phantoms under idealized external electron exposures

Nuclear Engineering and Technology
In the present study, a comprehensive dataset of dose coefficients for idealized external electron exposures has been established using the newly released ICRP-156 pediatric mesh-type reference computational phantoms (MRCPs) in conjunction with the ...
Chansoo Choi, Bangho Shin, Sungho Moon, Yeon Soo Yeom, Chan Hyeong Kim, Wesley E. Bolch   +5 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Dose coefficients for the ICRP pediatric mesh-type reference computational phantoms under idealized external photon exposure geometries

Nuclear Engineering and Technology
The International Commission on Radiological Protection (ICRP) recently released the pediatric mesh-type reference computational phantoms (MRCPs) through ICRP Publication 156 to overcome the limitations of the pediatric voxel-type reference computational
Chansoo Choi, Bangho Shin, Yeon Soo Yeom, Wesley E. Bolch, Chan Hyeong Kim   +4 more
doaj   +1 more source

A method for mapping and quantifying whole organ diffusion-weighted image distortion in MR imaging of the prostate

Scientific Reports, 2017
A computational algorithm was designed to produce a measure of DW image distortion across the prostate. This algorithm was tested and validated on virtual phantoms incorporating known degrees and distributions of distortion.
Andrew B. Gill, Marcin Czarniecki, Ferdia A. Gallagher, Tristan Barrett   +3 more
doaj   +1 more source