Results 121 to 130 of about 8,287,486 (375)

Educational Computing and Computer Science

Issues and Trends in Educational Technology, 2015
The resurgence of interest in teaching computational thinking (CT) to K-12 students is an opportunity to provide students with a critical foundational skill. This will only be possible, however, if CT is understood to be separable from the more specific field of Computer Science.
openaire   +4 more sources

Computational Thinking Integration into Middle Grades Science Classrooms: Strategies for Meeting the Challenges [PDF]

, 2018
This paper reports findings from the efforts of a university-based research team as they worked with middle school educators within formal school structures to infuse computer science principles and computational thinking practices.
Akram, Bita, Aksit, Osman, Boyer, Kristy Elizabeth, Buffum, Philip Sheridan, Cadieux Boulden, Danielle, Lester, James, Mott, Bradford, Wiebe, Eric   +7 more
core   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Mechanistic models in computational social science

Frontiers in Physics, 2015
Quantitative social science is not only about regression analysis or, in general, data inference. Computer simulations of social mechanisms have an over 60 years long history. They have been used for many different purposes—to test scenarios, to test the
Petter eHolme, Fredrik eLiljeros
doaj   +1 more source

Computational Archival Science [PDF]

Moderna arhivistika, 2018
The digitisation of archival materials and ingest of digitally born materials in digital archives has led to the possibilities of application of the big data analytical principles in the digital archives. The author explains the 5V characteristics of big data. He proceeds to define the concept of Computational Archival Science (CAS).
openaire   +2 more sources

Looking for Design in Materials Design

, 2004
Despite great advances in computation, materials design is still science fiction. The construction of structure-property relations on the quantum scale will turn computational empiricism into true design.Comment: 3 pages, 1 ...
CS Smith, D. P. Clougherty, L Chang, LEK Achenie, M. E. Eberhart, RB Woodward   +5 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Is computer science dying? [PDF]

2016 International Conference on Embedded Computer Systems: Architectures, Modeling and Simulation (SAMOS), 2016
This talk discusses some positive and negative trends in the field. It briefly examines some case studies, and finally discusses things that we as a community could do better.
openaire   +3 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source