Results 211 to 220 of about 491,707 (327)

MGPT: A Multi‐task Graph Prompt Learning Framework for Drug Discovery

Advanced Science, EarlyView.
MGPT is a unified multi‐task graph prompt learning model providing generalizable and robust graph representations for few‐shot drug association prediction. MGPT demonstrates the ability of seamless task switching and outperforms competitive approaches in few‐shot scenarios.
Yang Li, Youhan Sun, Xinyu Qin, Xin Gao, Guohua Wang   +4 more
wiley   +1 more source

3D Hyperbolic Kirigami Metamaterials With Tunable Auxeticity and Multistability

Advanced Science, EarlyView.
This study proposes a hyperbolic tessellation‐based structure that integrates TPMSs (Triply Periodic Minimal Surfaces, including SP: Schwarz Primitive, SD: Schwarz Diamond, and GY: Gyroid) with rotating rigid polygons, which enables 3D scalable deformation. The structure exhibits auxeticity and multistability, with a maximum volume expansion rate of up
Yu Lei, Yan Wang, Ruizhi Cui, Xiaolong Huang, Lei Zhang, Yuan Jin, Jinling Gao, Biwei Deng   +7 more
wiley   +1 more source

Towards Nonlinearity: The <i>p</i>-Regularity Theory. [PDF]

Entropy (Basel)
Bednarczuk E, Brezhneva O, Leśniewski K, Prusińska A, Tret'yakov AA.   +4 more
europepmc   +1 more source

Programmable DNA‐Based Molecular Neural Network Biocomputing Circuits for Solving Partial Differential Equations

Advanced Science, EarlyView.
This research introduces an augmented matrix‐based DNA molecular neural network to achieve molecular‐level solving of biological Brusselator PDEs. Crucial innovations include: (i) an augmented matrix‐based DNA molecular neural network, enabling multidimensional parameter integration through DNA strand displacement cascades and iterative weight ...
Yijun Xiao, Alfonso Rodríguez‐Patón, Jianmin Wang, Pan Zheng, Tongmao Ma, Tao Song   +5 more
wiley   +1 more source

A study of traveling wave solutions and modulation instability in the (3+1)-dimensional Sakovich equation employing advanced analytical techniques. [PDF]

Sci Rep
Ahmad J, Hameed M, Mustafa Z, Pervaiz F, Nadeem M, Alsayaad Y.   +5 more
europepmc   +1 more source

The Potential of Cognitive‐Inspired Neural Network Modeling Framework for Computer Vision

Advanced Science, EarlyView.
In article number 202507730, Guorun Li, Lei Liu, Yuefeng Du, and co‐workers present a cognitive modeling framework (CMF) to bridge the ‘representation gap’ and ‘conceptual gap’ between cognitive theory and vision deep neural networks (VDNNs). The research findings provide new insights and solid theoretical support for VDNN modeling inspired by ...
Guorun Li, Lei Liu, Xiaoyu Li, Yuefeng Du, Zhenghe Song, Xiuheng Wu   +5 more
wiley   +1 more source

Investigating topological descriptor and Gibb's energy for semiconducting carbon allotrope through advanced curve fitting model. [PDF]

Sci Rep
Almohanna NE, Asif M, Alhulwah KH, Hanif MF, Siddiqui MK, Fiidow OA.   +5 more
europepmc   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, EarlyView.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

A novel fractal fractional mathematical model for HIV/AIDS transmission stability and sensitivity with numerical analysis. [PDF]

Sci Rep
Khan M, Khan N, Ullah I, Shah K, Abdeljawad T, Abdalla B.   +5 more
europepmc   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source