Results 221 to 230 of about 500,399 (326)

A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease

open access: yesAdvanced Science, EarlyView.
A minimal computational model of cellular aggregate formation in neurodegenerative disease, encompassing two competing processes: cell‐autonomous and cell‐to‐cell triggers of aggregation, is presented. Despite its simplicity, the model can reproduce the aggregate patterns observed in post‐mortem brain images from the primary tauopathy Progressive ...
Shih‐Huan Huang   +8 more
wiley   +1 more source

Machine learning predictions from unpredictable chaos. [PDF]

open access: yesJ R Soc Interface
Jiang J   +9 more
europepmc   +1 more source

High‐Temperature Single‐Photon Emission From Covalently Functionalized van der Waals Heterostructures

open access: yesAdvanced Science, EarlyView.
Covalent diazonium functionalization of graphite‐WSe2 heterostructures produces high‐purity single‐photon emission from WSe2 at T = 90 K, far above the typical T = 10 K limit. The chemical modification reshapes graphite's electronic structure and couples to WSe2 midgap states, stabilizing quantum emitters at elevated temperatures and opening pathways ...
S. Carin Gavin   +13 more
wiley   +1 more source

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

open access: yesAdvanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen   +11 more
wiley   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu   +11 more
wiley   +1 more source

Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing

open access: yesAdvanced Science, EarlyView.
This article presents the first mechanistic model for continuous lyophilization (aka freeze drying). The model accurately describes the key phenomena and critical process parameters in continuous lyophilization, which can be used for process design, optimization, and control. Results from this work can drive the transition of (bio)pharmaceutical freeze
Prakitr Srisuma   +2 more
wiley   +1 more source

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