Results 41 to 50 of about 35,918 (305)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Selective hydrogenation of 5-(hydroxymethyl)furfural to 5-methylfurfural over single atomic metals anchored on Nb2O5

Nature Communications, 2021
Selective hydrogenation of 5-(hydroxymethyl)furfural (HMF) to 5-Methylfurfural using H2 as reductant is very attractive, but remains challenging. Here, the authors report that isolated single atomic catalysts can catalyze the reaction efficiently with ...
Shaopeng Li, Minghua Dong, Junjuan Yang, Xiaomeng Cheng, Xiaojun Shen, Shulin Liu, Zhi-Qiang Wang, Xue-Qing Gong, Huizhen Liu, Buxing Han   +9 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Outlining the impact of melting on MHD Casson fluid flow past a stretching sheet in a porous medium with radiation

Heliyon, 2019
This article focused on framing the features of melting heat transfer on magnetohydrodynamic (MHD) Casson fluid flow in a porous medium influenced by thermal radiation.
Fazle Mabood, Kalidas Das
doaj   +1 more source

Maxwell's Demon and the Thermodynamics of Computation [PDF]

Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics, 2001
It is generally accepted, following Landauer and Bennett, that the process of measurement involves no minimum entropy cost, but the erasure of information in resetting the memory register of a computer to zero requires dissipating heat into the environment. This thesis has been challenged recently in a two-part article by Earman and Norton.
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Physical Intelligence and Thermodynamic Computing [PDF]

Entropy, 2017
This paper proposes that intelligent processes can be completely explained by thermodynamic principles. They can equally be described by information-theoretic principles that, from the standpoint of the required optimizations, are functionally equivalent. The underlying theory arises from two axioms regarding distinguishability and causality.
openaire   +2 more sources

Application of computational fluid dynamics to turbo machinery unsteady aerodynamics and aero acoustics [PDF]

, 2008
The aim of this thesis is to obtain numerical data for fan tone noise propagation and reducing the load from blade-tower interaction. By using a CFD code, MB3D, which is supplied by Professor Li He, fan tone noise transmission and wind turbine blade ...
Dong, Ying
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

SEGREGATION IN HSLA STEELS FOR SOUR SERVICE: AN EVALUATION USING COMPUTATIONAL THERMODYNAMICS [PDF]

Tecnologia em Metalurgia, Materiais e Mineração, 2014
The amount, type and distribution of non-metallic inclusions as well as the solidification segregation, which influences inclusion type and distribution, have great influence on the performance of High Strength Low Alloy (HSLA) steels used in sour ...
André Luiz Vasconcellos da Costa e Silva
doaj   +1 more source