Results 231 to 240 of about 73,306 (292)

Integration of Machine Learning With PBPK and QSAR Modeling Approaches to Facilitate Drug Discovery and Development

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 4, April 2026.
ABSTRACT This review examines the application of machine learning (ML) in physiologically based pharmacokinetic (PBPK) modeling through improved prediction of input parameters, particularly via quantitative structure–activity relationship (QSAR) models, for absorption, distribution, metabolism, and excretion (ADME) properties across drug development ...
Xinyue Chen, Zhoumeng Lin
wiley   +1 more source

Editorial: Next generation chemical risk assessment: integration of advances in toxicology, biology and computation

Frontiers in Toxicology
Kan Shao, Kan Shao, Chao Ji, Bernard Gadagbui   +3 more
doaj   +1 more source

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, Volume 101, Issue 2, Page 848-868, April 2026.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

Beyond QSARs: Quantitative Knowledge-Activity Relationships (QKARs) for enhanced drug toxicity prediction. [PDF]

Toxicol Sci
Li T, Qu Y, Chen A, Thakkar S, Li D, Tong W.   +5 more
europepmc   +1 more source

Machine Learning Model for an App‐Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 2, Page 236-246, April 2026.
Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon, Mathieu Montoya, Isabelle Gourdon   +2 more
wiley   +1 more source

Editorial: Advances and applications of predictive toxicology in knowledge discovery, risk assessment, and drug development. [PDF]

Front Pharmacol
Zhang F, Li F, Tan J, Zhang N, Han Y, Liao J, Zhai H.   +6 more
europepmc   +1 more source

Mechanistic insights into triclosan-induced hepatotoxicity: A network toxicology and molecular docking approach. [PDF]

PLoS One
Liu F, Zhao Y, Zhu D, Wang J, Zhuang Z, Chen Y, Su Y, Tu Z.   +7 more
europepmc   +1 more source

Integrative Assessment of <i>Glycyrrhiza uralensis</i> Extract in Cosmetics Using HPLC Analysis, Network Pharmacology, and Computational Threshold of Toxicological Concern-Based Safety Evaluation. [PDF]

Int J Mol Sci
Kim H, Park K, Kim YB, Kim M.
europepmc   +1 more source

Navigating the AI Frontier in Toxicology: Trends, Trust, and Transformation. [PDF]

Curr Environ Health Rep
Luechtefeld T, Hartung T.
europepmc   +1 more source