Results 251 to 260 of about 3,211,994 (375)

Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu, Ian Sorrell, Fang Ma, Miaoran Ning, Yoen‐Ju Son, Gaohong She, Tom De Bruyn, Joshua Galanter, Nastya Kassir, Ryan Owen, Masoud Jamei, Iain Gardner, Yuan Chen   +12 more
wiley   +1 more source

Combined effects and potential mechanisms of phthalate metabolites on serum sex hormones among reproductive-aged women: An integrated epidemiology and computational toxicology study

Xiaoqian Li, Na Zheng, Wenhui Zhang, Yan Yu, Yunyang Li, Siyu Sun, Yining Ji, Sujing Wang   +7 more
openalex   +1 more source

Nanoparticle Skin Penetration: Depths and Routes Modeled In‐Silico

Small, EarlyView.
An in‐silico human skin model based on 20 years of NP penetration studies, incorporating 19 parameters is developed. Using random forest and Kennard‐Stone sorting, the model achieves 95% accuracy, identifying hair follicle diameter as the dominant penetration factor.
Natsumi Maeda, Haixin Jiao, Ilona Edyta Kłosowska‐Chomiczewska, Wojciech Artichowicz, Ulrich Preiss, Patrycja Szumała, Adam Macierzanka, Christian Jungnickel   +7 more
wiley   +1 more source

Computational Toxicology: A New Frontier in Predictive Toxicology

C K Gomathy, V. Geetha, H. Surendar, Sudha Ramakrishnan, V. Sanjay   +4 more
openalex   +1 more source

Exploring 2D Graphene‐Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective

Small Science, EarlyView.
Two‐dimensional graphene‐based nanomaterials are of significant interest in biomedical applications due to their unique physicochemical properties. Computational modeling provides useful insights into their structure and interactions with biological systems, aiding the nanoparticle design.
Alexa Kamboukos, Nevena Todorova, Irene Yarovsky   +2 more
wiley   +1 more source

Editorial: Methods in predictive toxicology 2023. [PDF]

Front Pharmacol
Jain S, Manganelli S, Gryshkova V, Rodrigues MA, Magarkar A.   +4 more
europepmc   +1 more source

Retraction Note: Decoding toxicological signatures through quantum computational paradigm [PDF]

Ishan Shivansh Bangroo, María Fernanda Del Cid Hernández, Ravi Kumar   +2 more
openalex   +1 more source

Pivotal Role of Multishelled Architecture in Nanoreactor with Spatial Confined Co3O4 for Peroxymonosulfate Activation and Contaminants Degradation

Small Structures, EarlyView.
Different shapes and structures of cobalt‐based catalysts, combinating with persulfate activation, were used on the degradation of tetracycline and bisphenol A This study offers novel insights into the factors contributing to the enhanced performance of cobalt‐based catalysts with varying shapes and structures.
Geng Li, Shiyu Bian, Wenting Sun, Yuwei Pan, Weinan Xing, Ying Zhang, Guangyu Wu, Yudong Huang   +7 more
wiley   +1 more source

QUANTUM-TOX - Revolutionizing Computational Toxicology with Electronic Structure Descriptors and Artificial Intelligence [PDF]

openalex   +1 more source

Correction: Computational evaluation of efflux pump homologues and lignans as potent inhibitors against multidrug-resistant Salmonella typhi. [PDF]

PLoS One
Shafique I, Rafiq M, Rana NF, Menaa F, Almalki F, Aljuaid A, Alnasser SM, Alotaibi AS, Masood MBE, Tanweer T.   +9 more
europepmc   +1 more source