Results 261 to 270 of about 2,598,515 (356)

Association of heart rate variability, exercise intensity and exercising arrhythmias with competition results in eventing horses

Equine Veterinary Journal, EarlyView.
Abstract Background Exercising arrhythmias are common in horses participating in eventing competitions. Heart rate variability (HRV) and a specific measure of the degree of heart rate fluctuation (Detrended Fluctuation Analysis alpha1; DFA‐α1) are proposed as exercise intensity and fatigue markers.
Cristobal Navas de Solis, Alessandra Ramseyer, Darko Stefanovski, Joanne Haughan, Claire J. Solomon, Katharina Kirsch   +5 more
wiley   +1 more source

Effect of high‐speed exercise on subchondral bone in the metacarpo−/metatarsophalangeal joints of 2‐year‐old Thoroughbred racehorses in their first year of training

Equine Veterinary Journal, EarlyView.
Abstract Background Stress‐induced bone injury can lead to catastrophic injuries in Thoroughbred racehorses. Accumulation of high‐speed exercise can increase the risk of subchondral bone injury. Objectives To investigate the effect of high‐speed exercise on the subchondral bone of the metacarpo–metatarsophalangeal (MCP/MTP) joints using standing cone ...
Sarah A. Ciamillo, Kathryn W. Bills, Taryn M. Gassert, Dean W. Richardson, Kara A. Brown, Darko Stefanovski, Kyla F. Ortved   +6 more
wiley   +1 more source

Using network toxicology and molecular docking to identify core targets and pathways underlying tacrolimus-induced tremor in organ transplant recipients. [PDF]

Sci Rep
Liu C, Chen Q, Yan F, Niu Y.
europepmc   +1 more source

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, EarlyView.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

Targeted drug screening for autism based on Cav1.2 calcium ion channel. [PDF]

PLoS One
Liu C.
europepmc   +1 more source

Tracing the molecular landscape of diabetic nephropathy: Insights from machine learning and experiment verification

Journal of Diabetes Investigation, EarlyView.
Diabetic nephropathy (DN) is a major complication of diabetes, leading to end‐stage renal disease. This study identified 109 differentially expressed genes (DEGs) and validated LOX as a novel diagnostic biomarker through integrated bioinformatics and experimental analysis.
Shahad W. Kattan, Ahmed M. Basri, Mohammad H. Alhashmi, Amany I. Almars, Reem Hasaballah Alhasani, Ifat Alsharif, Ikhlas A. Sindi, Ahmad H. Mufti, Iman S. Abumansour, Nasser A. Elhawary, Aishah Abdullah Qahtani, Hailah M. Almohaimeed   +11 more
wiley   +1 more source

In Silico Network Toxicology, Molecular Docking, and Multi-Level Bioinformatics Reveal Methyl Eugenol-Induced Hepatocellular Carcinoma Mechanisms in Humans. [PDF]

Cancer Med
Karakuş F, Tanrıverdi Z, Kuzu B.
europepmc   +1 more source

Phenotype‐Specific Semi‐Mechanistic Modelling of Florfenicol Time‐Kill Curves in G. Parasuis Compared to Other Respiratory Pathogens

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae and Pasteurella multocida. In vitro time‐kill assays and semi‐mechanistic PD modeling were used to assess bacterial growth and killing rates at varying ...
Andrew Mead, Abigail Hughes, Stefano Azzariti, Pierre‐Louis Toutain, Ludovic Pelligand   +4 more
wiley   +1 more source

ToxPoint: Chemical risks and children's health-building on progress based on science, not panic. [PDF]

Toxicol Sci
Cohen SM, Rietjens IMCM, Levy L, Alliance of Scientists for Evidence-Based Risk Assessment .   +3 more
europepmc   +1 more source