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Adventures in Computational Toxicology and Exposure
2017Presented to Bristol-Meyers ...
Kapraun, Dustin, 0000-0001-5570-6383
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ACToR — Aggregated Computational Toxicology Resource
Toxicology and Applied Pharmacology, 2008ACToR (Aggregated Computational Toxicology Resource) is a database and set of software applications that bring into one central location many types and sources of data on environmental chemicals. Currently, the ACToR chemical database contains information on chemical structure, in vitro bioassays and in vivo toxicology assays derived from more than 150
Richard M. Spencer +9 more
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2016
The advent of high speed computer systems has resulted in the evolution of the field of computational toxicology. The application of these computational tools to molecular biomarker development has facilitated the evolution of this field in a number of areas by accelerating access and appreciation of both the current state of knowledge about molecular ...
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The advent of high speed computer systems has resulted in the evolution of the field of computational toxicology. The application of these computational tools to molecular biomarker development has facilitated the evolution of this field in a number of areas by accelerating access and appreciation of both the current state of knowledge about molecular ...
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Application of a digital computer to emergency toxicology
Clinica Chimica Acta, 1974Abstract A digital computer has been applied to the laboratory diagnosis of drug overdose. Analytic data is entered by the technologist at a keyboard in response to computer instructions. Major and minor ultraviolet absorption peaks, pH dependent spectral shifts, and peak absorbance ratios are used for decision making.
Peter Jatlow, David Seligson
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Applicability of Computational Systems Biology in Toxicology
Basic & Clinical Pharmacology & Toxicology, 2014AbstractSystems biology as a research field has emerged within the last few decades. Systems biology, often defined as the antithesis of the reductionist approach, integrates information about individual components of a biological system. In integrative systems biology, large data sets from various sources and databases are used to model and predict ...
Niels Hadrup +3 more
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[The development of computational toxicology and application in risk assessment of chemicals].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2019The number of new chemicals increases tremendously annually, while traditional time-and cost-consuming toxicity tests based on animals with the uncertainty of extrapolation could not meet the demand of hazard identification and risk assessment.
R. Zhang, W. Chen
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Computational toxicology in drug safety research
Folia Pharmacologica Japonica, 2023The progress of computational toxicology (CompTox) in drug safety research is highly anticipated. CompTox provides toxicity screening methods for drug discovery in the early stages. CompTox also contributes to fostering the application of the principles of the 3Rs in toxicity testing by expanding non-animal test methods.
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Computational Toxicology: Application in Environmental Chemicals
2012This chapter provides an overview of computational models that describe various aspects of the source-to-health effect continuum. Fate and transport models describe the release, transportation, and transformation of chemicals from sources of emission throughout the general environment.
Curtis C. Dary +6 more
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Testing computational toxicology models with phytochemicals
Molecular Nutrition & Food Research, 2010AbstractComputational toxicology employing quantitative structure–activity relationship (QSAR) modeling is an evidence‐based predictive method being evaluated by regulatory agencies for risk assessment and scientific decision support for toxicological endpoints of interest such as rodent carcinogenicity. Computational toxicology is being tested for its
R. Daniel Benz +5 more
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