Results 101 to 110 of about 1,070,811 (318)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Radiomics and Clinical Characters Based Gaussian Naive Bayes (GNB) Model for Preoperative Differentiation of Pulmonary Pure Invasive Mucinous Adenocarcinoma From Mixed Mucinous Adenocarcinoma

Technology in Cancer Research & Treatment
Objective: To develop and validate predictive models based on clinical parameters, and radiomic features to distinguish pulmonary pure invasive mucinous adenocarcinoma (pIMA) from mixed mucinous adenocarcinoma (mIMA) before surgery.
Junjie Zhang MD, Ligang Hao MD, Qian Xu MD, Fengxiao Gao MD   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Experimental investigations on the structural resolution in metrological computed tomography [PDF]

, 2017
In the recent years, X-ray computed tomography (CT) has been successfully applied as an innovative coordinate measurement technology in industrial metrology.
SIMONE CARMIGNATO, FILIPPO ZANINI
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Velocity Estimation in Mixtures using Tomography [PDF]

, 2000
In oil production a lot of water is usually pumped up together with the oil. For many reasons the reduction of the water production is a very important issue. The method presented in this paper is meant to provide a necessary tool for this. Most drilling
Hochstenbach, M.E., Schilders, W.H.A., Terra, G.M., Molenaar, J., Schilders, W.H.A, Hochstenbach, M., Moienaar, J., Cahyono, E.   +7 more
core  

Development and Validation of Predictive Models for Differentiating Resectable Stage III Peripheral SCLC from NSCLC Using Radiomic Features and Clinical Parameters

Technology in Cancer Research & Treatment
Objective Lung cancer is primarily categorized into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), each characterized by distinct therapeutic approaches and prognostic outcomes, particularly in stage III peripheral cases.
Junjie Zhang MD, Ligang Hao MD, Qiuxu Zhang MD, Lina Zheng MD, Qian Xu PhD, Fengxiao Gao MD   +5 more
doaj   +1 more source

Dynamic muscle damage monitoring in pig crush injury: T2-weighted Dixon and 2D ultrasound applications

Frontiers in Veterinary Science
BackgroundCrush injury (CI) involves compressive trauma causing muscle swelling, compartment syndrome, and neurological damage. We examined T2-Dixon and ultrasound for CI evaluation in pigs, integrating imaging with lab and tissue findings.MethodsTwelve ...
Guangda Wang, Guangda Wang, Jiayi Wang, Dou Li, Qi Wang, Zikuo Zhao, Rongbang Chen, Qi Lv, Haojun Fan   +8 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Development of a prognostic nomogram for esophageal squamous cell carcinoma patients received radiotherapy based on clinical risk factors

Frontiers in Oncology
PurposeThe goal of the study was to create a nomogram based on clinical risk factors to forecast the rate of locoregional recurrence-free survival (LRFS) in patients with esophageal squamous cell carcinoma (ESCC) who underwent radiotherapy (RT).MethodsIn
Yang Li, Xian Shao, Li-Juan Dai, Meng Yu, Meng-Di Cong, Jun-Yi Sun, Shuo Pan, Gao-Feng Shi, An-Du Zhang, Hui Liu   +9 more
doaj   +1 more source