Results 61 to 70 of about 871,431 (301)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Imaging an intrapulmonary solitary fibrous tumor with CT and F-18 FDG PET/CT

Radiology Case Reports, 2019
Intrapulmonary solitary fibrous tumors (SFTs) are extremely rare neoplasms. We report a case of an intrapulmonary SFT and describe the findings of computed tomography (CT) and F-18 fluorodeoxyglucose positron emission tomography.
Takayoshi Shinya, MD, PhD, Yoshihisa Masaoka, MD, PhD, Motohiro Sando, MD, Shin Tanabe, MD, Soichiro Okamoto, MD, Hiroki Ihara, MD, PhD, Takehiro Tanaka, MD, PhD, Shinji Otani, MD, PhD, Takao Hiraki, MD, PhD, Susumu Kanazawa, MD, PhD   +9 more
doaj   +1 more source

Dynamic contrast enhanced CT in nodule characterization: How we review and report [PDF]

, 2016
Incidental indeterminate solitary pulmonary nodules (SPN) that measure less than 3 cm in size are an increasingly common finding on computed tomography (CT) worldwide. Once identified there are a number of imaging strategies that can be performed to help
Eaton, RJ, Gilbert, FJ, Miles, K, Qureshi, NR, Shah, A, Sputnik investigators   +5 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

First-line treatments for extensive-stage small-cell lung cancer with immune checkpoint inhibitors plus chemotherapy: a China-based cost-effectiveness analysis

Frontiers in Immunology
ObjectiveTo determine the cost-effectiveness of imported immune checkpoint inhibitors (ICIs) such as atezolizumab and durvalumab, and domestic ICIs like serplulimab and adebrelimab, in combination with chemotherapy for extensive-stage small cell lung ...
Lidan Yi, Zhen Zhou, Xiaohui Zeng, Chongqing Tan, Qiao Liu   +4 more
doaj   +1 more source

Single Photon Emission Computed Tomography-Computed Tomography (SPECT-CT) Use in Osteosarcoma with Lung Uptake [PDF]

, 2014
A 15-year-old patient with osteosarcoma of left distal femur underwent a bone scan with Tc-99m hydroxymethylenediphosphonate (HDP). Whole body bone scan revealed extensive bone and thoracic metastases.
Abdul Hamid, Khadijah, Ahmad Sarji, Sazilah   +1 more
core  

Computed tomography-osteoabsorptiometry for assessing the density distribution of subchondral bone as a measure of long-term mechanical adaptation in individual joints [PDF]

, 1989
To estimate subchondral mineralisation patterns which represent the long-term loading history of individual joints, a method has been developed employing computed tomography (CT) which permits repeated examination of living joints.
A Schleicher, B Kummer, B Kummer, Berthold Wimmer, E Amtmann, Erik Schulte, F Pauwels, GU Rao, H Konermann, H Molzberger, HE Meema, HK Genant, J Adams, J Noble, J-J Knief, K Kouris, Magdalena M�ller-Gerbl, N Möllers, Norbert Hodapp, P Maquet, P Steiger, Reinhard Putz, SB Murphy, WA Kalender   +23 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The PROMISE-V2 PRIMARY score and SULmax [18F]PSMA-1007 PET/CT in primary staging of prostate cancer

Journal of the Mexican Federation of Radiology and Imaging
Introduction: The PRIMARY score of the PROMISE-V2 criteria for primary staging of prostate cancer (PCa) and its relationship with the maximum standardized uptake value normalized to lean body mass (SULmax) have not been evaluated.
J. Antonio Serna-Macias, M. Lourdes Garcia-Colmenero, Emilly A. Cortes-Mancera, E. David Muñoz-Carpio, Mixel Z. Baltierra-Hernandez   +4 more
doaj   +1 more source

EGFR inhibitor as second-line therapy in a patient with mutant RAS metastatic colorectal cancer: circulating tumor DNA to personalize treatment [PDF]

, 2018
A 47-year-old male patient presented in March 2016 to our unit with a palpable painless left supraclavicular mass. A whole-body contrastenhanced computed tomography (CT) scan revealed a left supraclavicular lymphadenopathy, transverse colon thickening ...
Cortesi, Enrico, Gazzaniga, Paola, Raimondi, Cristina, Urbano, Federica   +3 more
core   +1 more source