Results 101 to 110 of about 445,823 (307)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Automated Computer-Aided Detection of Lung Nodules in Metastatic Colorectal Cancer Patients for the Identification of Pulmonary Oligometastatic Disease

open access: green, 2022
Jason Joon Bock Lee   +9 more
openalex   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Soil, water, and vegetation conditions in south Texas [PDF]

open access: yes
The author has identified the following significant results. Software development for a computer-aided crop and soil survey system is nearing completion.
Everitt, J. H.   +5 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

MMTransformer: a multivariate time-series resource forecasting model for multi-component applications

open access: yesScientific Reports
Efficient resource forecasting in multi-component application scenarios necessitates comprehensive consideration of inter-component dependencies and resource interaction characteristics.
Guangzhang Cui   +3 more
doaj   +1 more source

Energy Integration and WEP Technical Evaluation of a Large-Scale PVC Production Process

open access: yesSci
PVC has become an indispensable material worldwide. However, its production method (suspension) presents significant sustainability challenges, such as negative environmental impacts and high operational costs due to energy consumption.
Antonio Mendivil-Arrieta   +4 more
doaj   +1 more source

Computer-aided Circuit Analysis Semiannual Report, May 15 - Nov. 14, 1966 [PDF]

open access: yes
Digital computer aided circuit analysis and ...
Koonce, H. T., Yang, T.
core   +1 more source

Architectural Limitations in Multi-User Computer-Aided Engineering Applications [PDF]

open access: yes, 2013
The engineering design process evolves products by a collaborative synthesis of specifications, personnel and organizations. Unfortunately, collaborative effectiveness is thwarted by existing single-user computer-aided applications like computer-aided ...
Benzley, Steven   +5 more
core   +2 more sources

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