Results 111 to 120 of about 445,823 (307)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Design of 3D Scanning Technology Using a Method with No External Reference Elements and Without Repositioning of the Device Relative to the Object

open access: yesApplied Sciences
The use of 3D scanning technologies for surface scanning of objects is limited by environmental conditions and technology requirements based on their characteristics.
Adrián Vodilka   +4 more
doaj   +1 more source

Computer-aided circuit analysis Annual report, May 15, 1965 - May 14, 1966 [PDF]

open access: yes
Research on digital computer aided analysis of electric ...
Koonce, H. T., Yang, T.
core   +1 more source

Computer method for identification of boiler transfer functions [PDF]

open access: yes, 1971
Iterative computer aided procedure was developed which provides for identification of boiler transfer functions using frequency response data. Method uses frequency response data to obtain satisfactory transfer function for both high and low vapor exit ...
Miles, J. H.
core   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

A two-stage multi-scale attention-based network for weakly supervised cataract fundus image enhancement

open access: yesScientific Reports
Cataract is a major cause of vision loss and hinders further diagnosis. However, enhancing cataract fundus images remains challenging due to limited paired cataract retinal images and the difficulty of recovering fine details in the retinal images.
Xiaoyong Fang   +4 more
doaj   +1 more source

Correcting the Chromatic Aberration in Barrel Distortion of Endoscopic Images [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2003
Modern endoscopes offer physicians a wide-angle field of view (FOV) for minimally invasive therapies. However, the high level of barrel distortion may prevent accurate perception of image.
Y. M. Harry Ng, C. P. Kwong
doaj  

A bibliography on digital computer-aided circuit analysis and design [PDF]

open access: yes
Digital computer-aided electric logic circuit analysis and design ...
Yang, T.
core   +1 more source

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